Nitrite-dependent nitric oxide synthesis by molybdenum enzymes

FEBS Letters
Daniel Bender, Guenter Schwarz

Abstract

Nitric oxide (NO) is an important gasotransmitter involved in numerous intra- and intercellular signaling events. In addition to the oxidative pathway of NO generation, which includes three NO synthase (NOS) isoforms in mammals, a reductive pathway contributes to NO generation. In this pathway, nitrite is reduced to NO by various metal-containing proteins. Among these, all members of the eukaryotic molybdenum (Mo)-dependent enzyme family were found to be able to reduce nitrite to NO. This Review focuses on the current state of research in the field of Mo-dependent nitrite reduction in eukaryotes. An overview on the five eukaryotic Mo-enzymes is given, and similarities as well as differences in their nitrite reduction mechanisms are presented and discussed in the context of physiological relevance.

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Citations

Jun 26, 2018·FEBS Letters·Wilhelm Just
Jan 18, 2020·Journal of Inherited Metabolic Disease·Daniel BenderGuenter Schwarz
Aug 28, 2020·Frontiers in Plant Science·Arbindra TimilsinaChunsheng Hu
Mar 20, 2019·Plants·Marie Agatha MohnKatrin Fischer-Schrader
Aug 1, 2020·Frontiers in Plant Science·Katarzyna CiackaAgnieszka Gniazdowska
Sep 3, 2020·Journal of Experimental Botany·Antoine BergerRenaud Brouquisse
Nov 17, 2020·Journal of Experimental Botany·Rajesh Kumar TewariMasami Watanabe
Sep 22, 2019·Nitric Oxide : Biology and Chemistry·Zs KolbertJ T Hancock
Jan 13, 2021·International Journal of Molecular Sciences·Álvaro Costa-BrosetaJosé León
Aug 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thamara Figueiredo ProcópioThiago Henrique Napoleão
May 6, 2021·Biomolecules·Shirley JamesKuzhuvelil B Harikumar
Nov 17, 2020·Protein and Peptide Letters·Leydianne Leite de Siqueira PatriotaThiago Henrique Napoleáo
Oct 6, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Simon J MayrGuenter Schwarz

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