Nitro-fatty acid formation and metabolism

Nitric Oxide : Biology and Chemistry
Gregory J BuchanStacy Gelhaus Wendell

Abstract

Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.

Citations

Feb 29, 2020·Photochemistry and Photobiology·Fernanda M PradoPaolo Di Mascio
May 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bruna NevesTânia Melo
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Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena Kalinina, Maria Novichkova
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