PMID: 7544446Apr 1, 1995Paper

Nitroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism

Neurochemical Research
Elena KosenkoVicente Felipo

Abstract

We have proposed that acute ammonia toxicity is mediated by activation of the N-methyl-D-aspartate type of glutamate receptors. MK-801, a selective antagonist of these receptors, prevents death of animals induced by acute ammonia intoxication as well as ammonia-induced depletion of ATP. It seems therefore that, following activation of the N-methyl-D-aspartate receptors, the subsequent events in ammonia toxicity should be similar to those involved in glutamate neurotoxicity. As it has been shown that inhibitors of nitric oxide synthetase such as nitroarginine prevent glutamate toxicity, we have tested whether nitroarginine prevents ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. It is shown that nitroarginine prevents partially (approximately 50%), but significantly death of mice induced by acute ammonia intoxication. Nitroarginine also prevents partially ammonia-induced depletion of brain ATP. It also prevents completely the rise in glucose and pyruvate and partially that in lactate. Injection of nitroarginine alone, in the absence of ammonia, induces a remarkable accumulation of glutamine and a decrease in glutamate. The results reported indicate that nitroarginine attenuates acute amm...Continue Reading

References

Mar 1, 1977·The Journal of Clinical Investigation·B HindfeltT E Duffy
Nov 1, 1992·Journal of Neurobiology·D W Choi
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Jan 1, 1985·Methods in Enzymology·A Meister
Jul 15, 1988·Biochemical and Biophysical Research Communications·G Thomas, P W Ramwell
Jul 10, 1971·Lancet·J E Fischer, R J Baldessarini
Nov 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·B Hindfelt, B K Siesjö
Aug 1, 1973·The Biochemical Journal·R A HawkinsR L Veech
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M WettsteinD Häussinger

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Citations

Dec 18, 2001·Journal of Neuroscience Research·G BaiM D Norenberg
Oct 10, 2001·Journal of Neuroscience Research·C R MurthyM D Norenberg
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·A J Cooper
May 6, 2003·Brain Research·M Victoria GarcíaJosé M Medina
Jan 5, 2000·Journal of the Neurological Sciences·J Albrecht, E A Jones
May 17, 2000·Neurochemistry International·C R MurthyM D Norenberg
May 17, 2000·Neurochemistry International·L BuzańskaJ Albrecht
May 22, 2002·Neurochemistry International·Pilar MonfortVicente Felipo
May 22, 2002·Neurochemistry International·I SuárezB Fernández
Sep 16, 2003·Neurochemistry International·Takahiro KitanoSeiji Ito
Sep 5, 2002·Progress in Neurobiology·Vicente Felipo, Roger F Butterworth
Jul 13, 1999·Free Radical Biology & Medicine·E KosenkoV Felipo
Jun 19, 2007·Journal of Gastroenterology and Hepatology·Hui-Chun HuangShou-Dong Lee
Dec 18, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Elena A KosenkoCarmina Montoliu
Nov 4, 2006·Biological Chemistry·Freimut SchliessDieter Häussinger
Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura E Halpin, Bryan K Yamamoto
Jan 11, 2014·World Journal of Gastroenterology : WJG·Teresa R ScottDebbie L Shawcross
Jul 31, 2013·Life Sciences·Laura E HalpinBryan K Yamamoto
Feb 10, 1998·Free Radical Research·E KosenkoV Felipo
May 12, 2009·Neurochemistry International·Regina RodrigoVicente Felipo
Apr 26, 2008·Human Psychopharmacology·Brian H Harvey
Jul 29, 2015·PloS One·Vladimir V DynnikValery P Zinchenko
Jul 29, 2016·Neurochemical Research·Simo S OjaEsa R Korpi
Feb 7, 2004·European Journal of Clinical Investigation·C-Y ChanS-D Lee
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael D Norenberg
Jul 4, 2001·Journal of Neuroscience Research·J Albrecht, M Dolińska
Oct 1, 1996·Neurochemical Research·C HermenegildoV Felipo
Jul 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Omar CauliVicente Felipo
Mar 9, 2020·Metabolic Brain Disease·Ali SepehrinezhadRoger Williams
Dec 31, 2005·Metabolic Brain Disease·Jan Albrecht, Michał Wegrzynowicz
Aug 19, 2007·Metabolic Brain Disease·Marta LlansolaVicente Felipo
Dec 31, 2005·Metabolic Brain Disease·M D NorenbergA R Jayakumar

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