PMID: 15384835Sep 24, 2004Paper

Nitrogen balance studies and Kt/V urea in children undergoing chronic peritoneal dialysis

Advances in Peritoneal Dialysis
Francisco J CanoNelly Mazuel

Abstract

Currently, urea kinetic modeling has been accepted for the routine evaluation of peritoneal dialysis (PD) through the calculation of Kt/V (normalized whole body urea clearance) and nPNA (normalized protein equivalent of total nitrogen appearance). In pediatric dialysis, the exact meaning of and target values for, those parameters is still under debate. We evaluated the mean values and correlations between Kt/V urea and parameters of nutrition. During a 12-month period, we prospectively performed 186 nitrogen balance studies in pediatric patients on chronic PD. We also assessed daily protein intake (DPI) by nutritional evaluation. Protein, albumin, urea, and creatinine were analyzed in dialysate and urine, collected once monthly. Dialysis adequacy was evaluated using monthly measurements of Kt/V urea and creatinine clearance (CCr) in urine and dialysate. All statistical comparisons were performed using the paired t-test. Two-way analysis of variance for repeated measures was used to calculate correlations. A p value less than 0.05 was considered significant. We studied 20 patients (15 boys, 5 girls) of mean age 5.1 +/- 4.7 years (range: 3 months - 14.8 years). Mean DPI in these patients was 3.52 +/- 1.1 g/kg/day. Weekly total Kt...Continue Reading

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