PMID: 41244Sep 1, 1979

Nitrogen control in Salmonella: regulation by the glnR and glnF gene products

Proceedings of the National Academy of Sciences of the United States of America
S KustuN McFarland

Abstract

The product of the glnR gene is required for nitrogen regulation of the synthesis of glutamine synthesis (Gln synthetase) [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and two periplasmic transport proteins that are subject to nitrogen control in Salmonella. Strains with mutations to loss of function of the glnR product [e.g., a strain with a Tn10 insertion or one with an ICR-induced (frameshift) mutation in glnR] have about 3% as much Gln synthetase as a fully derepressed wild-type strain and are unable to increase synthesis of this enzyme or periplasmic transport proteins in response to nitrogen limitation. The structural gene for Gln synthetase, glnA, and those for the periplasmic transport proteins are unlinked on the chromosome; thus, glnR appears to encode a diffusible positive regulatory element. Consistent with this, the mutant glnR allele is recessive to the wild-type allele with regard to expression of glnA (synthesis of Gln synthetase). Although glnR is closely linked to glnA, strains with mutations to complete loss of function of the glnR product can be distinguished from glnA strains by their ability to produce detectable Gln synthetase and to grow in the absence of glutamine. To demonstrate unequivocally ...Continue Reading

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Citations

Jan 1, 1981·Molecular & General Genetics : MGG·G R Wei, S Kustu
Dec 1, 1987·Molecular & General Genetics : MGG·A BirkmannA Böck
Jan 1, 1983·Molecular & General Genetics : MGG·A A Covarrubias, F Bastarrachea
Jan 1, 1984·Molecular & General Genetics : MGG·S KustuJ C Meeks
Jan 1, 1982·Molecular & General Genetics : MGG·T MacNeilB Tyler
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Oct 1, 1984·Archives of Microbiology·H Castorph, D Kleiner
Feb 1, 1984·Archives of Biochemistry and Biophysics·C A JansonD Eisenberg
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Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D M RothsteinB Magasanik
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F FoorB Magasanik
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N McFarlandS Kustu
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R FisherR Haselkorn
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K BackmanB Magasanik
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·V SundaresanF M Ausubel
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Related Concepts

Carrier Proteins
Cistron
Genes, Regulator
Cis-Trans Test
Glutamate-Ammonia Ligase
Genetic Linkage Analysis
Nitrogen
Salmonella typhimurium LT2

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