Nitrogen Oxide Inhibitory Trimeric and Dimeric Carbazole Alkaloids from Murraya tetramera

Journal of Natural Products
Hai-Ning LvYong Jiang

Abstract

Two new structurally unique trimeric carbazole alkaloids, murratrines A and B (1, 2), and 11 new carbazole dimers, murradines A-K (3-13), and four known analogues (14-17) were isolated from the leaves and stems of Murraya tetramera. The structures and relative configurations of 1-13 were elucidated on the basis of comprehensive 1D and 2D NMR spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism (ECD) data analysis. Murratrines A and B (1, 2) both contain an unprecedented carbazole trimeric skeleton, and murradines A and D (3, 6) are the first natural C-1-C-3'-methyl-linked and C-6-C-3'-methyl-linked dimeric carbazole alkaloids, respectively. Compounds 4, 10, 14, 15, and 17 exhibited inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range of 11.2-19.3 μM.

References

Nov 14, 2002·Chemical Reviews·Hans-Joachim Knölker, Kethiri R Reddy
Apr 26, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C ItoH Furukawa
Dec 28, 2006·Journal of Natural Products·Min ChenDao-Feng Chen
Jul 5, 2007·Journal of Natural Products·Ya-Ching ShenAshraf Taha Khalil
Apr 7, 2012·Chemical Reviews·Arndt W SchmidtHans-Joachim Knölker
Aug 29, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Xue YouZhi-Wei Deng
Jan 27, 2015·Journal of Natural Products·Hai-Ning LvYong Jiang

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Citations

Aug 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Xue YouZhi-Wei Deng
Mar 10, 2017·Journal of Asian Natural Products Research·Wei HePeng-Fei Tu
Apr 5, 2018·Frontiers in Chemistry·Haishan LiuWeiming Zhu
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Xue YouXiao-Xue Yu
Jan 6, 2018·Journal of Natural Products·Bing-Yu LiuYong Jiang

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