Abstract
The efficacy and tolerability of nitroglycerin (NTG) ointment were studied in 80 male patients with severe angina pectoris. Two symptom-limited exercise tests were performed on successive days after application of an ointment containing 15 mg NTG or a placebo (P) ointment. The patients were assigned to 4 groups. The study was conducted in a double-blind, cross-over manner. The total amount of work performed was higher in all groups on NTG (46-70%) compared to P ointment. The difference was statistically significant (p less than 0.001) at all points of time from 0.5 to 7 hours. The ST segment depression in ECG at the end of the exercise test was slightly greater on P than on NTG, but the difference was statistically significant only in the 3-hour group (p less than 0.01). The frequencies of headache and dizziness were 35% and 16%, respectively, on NTG. Eight patients (10%) reported that headache was severe enough to prevent regular use of NTG ointment. NTG ointment is effective, has a long duration of action and is relatively well tolerated by patients with severe angina pectoris.
References
Jan 1, 1978·Cardiology·P A ChandraratnaS San Pedro
Dec 1, 1979·Postgraduate Medical Journal·H H Salem, S P Singh
Nov 1, 1978·American Heart Journal·D L KarshR A Langou
Jul 1, 1977·The American Journal of Cardiology·T HardarsonR A O'Rourke
Jan 1, 1978·Chest·N A AwanD T Mason
Oct 6, 1975·The American Journal of Cardiology·H GreenbergB H Pinkernell
Oct 1, 1976·The American Journal of Cardiology·W R TaylorH J Swan
Oct 1, 1976·British Heart Journal·S G MeisterW S Frankl
Apr 1, 1976·Angiology·M E Davidov, W J Mroczek
Aug 1, 1974·Circulation·N ReichekS E Epstein
Apr 1, 1980·The American Journal of Cardiology·R SlutskyW Ashburn
Oct 1, 1980·The American Journal of Cardiology·P W ArmstrongG S Marks
May 1, 1981·The American Journal of Cardiology·J A SalernoP Bobba
Dec 1, 1981·Circulation·B G BrownH T Dodge
Dec 1, 1981·Circulation·R L Feldman, C R Conti
Feb 1, 1982·The American Journal of Cardiology·U ThadaniJ O Parker
Sep 1, 1955·The American Journal of the Medical Sciences·J A DAVIS, B H WIESEL
Citations
Jan 1, 1990·European Journal of Clinical Pharmacology·J O Parker
Jan 1, 1989·Cardiovascular Drugs and Therapy·J O Parker
Jan 1, 1989·Cardiovascular Drugs and Therapy·H KishidaH Kitagawa
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·F Lund
Jun 25, 1987·The New England Journal of Medicine·J O Parker
Apr 1, 1986·British Journal of Clinical Pharmacology·A McAllisterJ A Steiner
Feb 19, 1998·The New England Journal of Medicine·J D Parker, J O Parker
Sep 13, 2018·Experimental Biology and Medicine·Stephen J JonesPaul A Beales
Jun 25, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil J WimalawansaDonald R Hoover