PMID: 6405584Jan 1, 1983Paper

Nitroglycerin ointment effective for seven hours in severe angina pectoris

Acta Medica Scandinavica
R KalaP I Halonen

Abstract

The efficacy and tolerability of nitroglycerin (NTG) ointment were studied in 80 male patients with severe angina pectoris. Two symptom-limited exercise tests were performed on successive days after application of an ointment containing 15 mg NTG or a placebo (P) ointment. The patients were assigned to 4 groups. The study was conducted in a double-blind, cross-over manner. The total amount of work performed was higher in all groups on NTG (46-70%) compared to P ointment. The difference was statistically significant (p less than 0.001) at all points of time from 0.5 to 7 hours. The ST segment depression in ECG at the end of the exercise test was slightly greater on P than on NTG, but the difference was statistically significant only in the 3-hour group (p less than 0.01). The frequencies of headache and dizziness were 35% and 16%, respectively, on NTG. Eight patients (10%) reported that headache was severe enough to prevent regular use of NTG ointment. NTG ointment is effective, has a long duration of action and is relatively well tolerated by patients with severe angina pectoris.

References

Dec 1, 1979·Postgraduate Medical Journal·H H Salem, S P Singh
Oct 1, 1976·The American Journal of Cardiology·W R TaylorH J Swan
Oct 1, 1976·British Heart Journal·S G MeisterW S Frankl
Oct 1, 1980·The American Journal of Cardiology·P W ArmstrongG S Marks
Dec 1, 1981·Circulation·R L Feldman, C R Conti
Sep 1, 1955·The American Journal of the Medical Sciences·J A DAVIS, B H WIESEL

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Citations

Jan 1, 1990·European Journal of Clinical Pharmacology·J O Parker
Jan 1, 1989·Cardiovascular Drugs and Therapy·J O Parker
Jan 1, 1989·Cardiovascular Drugs and Therapy·H KishidaH Kitagawa
Jun 25, 1987·The New England Journal of Medicine·J O Parker
Feb 19, 1998·The New England Journal of Medicine·J D Parker, J O Parker
Sep 13, 2018·Experimental Biology and Medicine·Stephen J JonesPaul A Beales
Jun 25, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil J WimalawansaDonald R Hoover

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