PMID: 9420823Sep 1, 1995Paper

Nitroimidazoles for imaging hypoxic myocardium

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
H W StraussK Linder

Abstract

A series of radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic tissue. Myocardium with an intracellular pO2 < 3 mm Hg (about 25% of normal), which has lost its contractile ability but has maintained its ability to catabolize glucose, can be localized with this imaging technique. When a nitroimidazole enters a viable cell, the molecule undergoes a series of reactions: Initially, the molecule gains a single electron by an enzymatic process in the cytoplasm to form a potentially reactive species, then in the presence of adequate intracellular oxygen levels the molecule is reoxidized. These reactions are repeated until the intact molecule diffuses back out of the cell. In myocytes with reduced oxygen concentration, the reoxidation does not take place, the reactive species appears to undergo additional reduction reactions and remains in the cell. The association of the reduced nitroimidazole and other cellular elements is not irreversible, since these agents clear from hypoxic tissue with a half-life of 4 to 8 hours. In one of the first nitroimidazoles used for in ...Continue Reading

References

Jul 1, 1991·Journal of Medicinal Chemistry·J E BiskupiakK A Krohn
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·P A JerabekM J Welch
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Citations

Feb 17, 2001·Biochemical and Biophysical Research Communications·M SubbarayanH Mukhtar
Jun 1, 1996·European Journal of Nuclear Medicine·H W Strauss
Sep 8, 1997·European Journal of Nuclear Medicine·L H Opie, B Hesse
Sep 28, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S MurugesaA M Samuel
Sep 5, 2002·Journal of Photochemistry and Photobiology. B, Biology·S MurugesanO P D Noronha
Jul 11, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·D Jain, P H McNulty
Jul 26, 2011·Journal of Molecular and Cellular Cardiology·M G HandleyR Southworth
Mar 16, 2004·Stroke; a Journal of Cerebral Circulation·Kazuko SaitaDavid W Howells
Mar 9, 2018·Current Cardiovascular Imaging Reports·Victoria R PellRichard Southworth
Oct 26, 1999·Seminars in Nuclear Medicine·A J Sinusas
Aug 26, 2021·Antioxidants & Redox Signaling·Jeffrey BrenderShun Kishimoto

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