PMID: 412966Dec 1, 1977

Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae

Journal of Medicinal Chemistry
R C TweitS Ziecina

Abstract

Nitroimidazoles have been prepared which show interesting activity against the bacterium, Neisseria gonorrhoeae, in addition to the activities usually shown by nitroimidazoles against protozoa and anaerobic bacteria. The compounds were prepared by alkylation of 1-methyl-2-mercaptoimidazole, followed by nitration. Optimum activity occurs with a 5-nitro group and a free carboxyl at the end of the group attached to the sulfur. The linkage between the sulfur atom and the carboxyl group can be alkylene or phenoxyalkylene. These compounds have only weak activity against other aerobic or facultative bacteria.

Citations

Apr 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·A BarrowC M Walls
Jan 1, 1985·Molecular and Biochemical Parasitology·N YarlettM Müller
Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·M CastelliG Baggio
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·E J GoldsteinS M Finegold

Related Concepts

Antibiotics
Fungus Drug Sensitivity Tests
Neisseria gonorrhoeae
Nitroimidazoles
Structure-Activity Relationship

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