Nitroprusside decreases the early post-denervation depolarization of diaphragm muscle fibres of the rat

European Journal of Pharmacology
A K UrazaevF Vyskocil

Abstract

The application of sodium nitroprusside, which degrades to nitric oxide (NO) in solution, inhibits early post-denervation depolarization of isolated rat diaphragm fibres. The observation that "old' solutions of sodium nitroprusside (that have been allowed to decompose) are without effect and that haemoglobin, oxadiazolo quinoxalinone (ODQ) and methylene blue can antagonize the inhibition normally produced by sodium nitroprusside suggests that the inhibitory effects of sodium nitroprusside on early post-denervation depolarization are mediated by NO and guanylyl cyclase. This is in accord with our recent observations with NO synthase activation and inhibition in the diaphragm.

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Citations

Jan 21, 2016·Acta Physiologica·Sergej Pirkmajer, Alexander V Chibalin
Dec 18, 2001·Microscopy Research and Technique·D Blottner, G Lück
Dec 19, 2001·Microscopy Research and Technique·M StangelR Gold
Dec 18, 2001·Microscopy Research and Technique·Z Grozdanovic
May 12, 2016·American Journal of Physiology. Endocrinology and Metabolism·Sergej Pirkmajer, Alexander V Chibalin
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner

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