PMID: 9161655May 1, 1997Paper

Nitroprusside treatment of erythromelalgia in an adolescent female

The Annals of Pharmacotherapy
J D StoneD R Allington

Abstract

To report a case of erythromelalgia in an adolescent patient successfully treated with nitroprusside. A 15-year-old girl with erythromelalgia resistant to aspirin therapy received an infusion of nitroprusside. The response of the erythromelalgia to nitroprusside was dramatic, with complete pain resolution within 17 hours after the start of therapy. No relapse of erythromelalgia was seen when nitroprusside was discontinued and the patient remained well after 6 months. This case adds to existing literature substantiating the benefit of nitroprusside for the treatment of erythromelalgia in pediatric patients. Erythromelalgia in children may represent a different disease entity than that seen in adults, which is commonly responsive to aspirin therapy. The pathogenesis of erythromelalgia is unclear and precludes formulating a proposed mechanism by which nitroprusside has benefit in children. Nitroprusside is valuable for erythromelalgia resistant to aspirin therapy in pediatric patients. Because of unanswered questions regarding the disease, aspirin remains the agent of first choice in all patients with this rare disease.

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Citations

Nov 23, 2006·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Charles J Buttaci
Oct 29, 2011·Vascular Medicine·Nedaa SkeikRandal C Richardson
Mar 15, 2006·Current Treatment Options in Cardiovascular Medicine·Mark D P Davis, Thom Rooke
Nov 27, 2015·Case Reports in Medicine·Rosario RussoAntonio Russo
May 11, 2002·Current Treatment Options in Cardiovascular Medicine·Mark D. P. Davis, Thom Rooke
Feb 19, 2002·The Annals of Pharmacotherapy·Jay S Cohen
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson

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