Nitrosamine carcinogenicity: a quantitative relationship between molecular structure and organ selectivity for a series of acyclic N-nitroso compounds

Chemico-biological Interactions
A S EdelmanJ S Wishnok


A mathematical model has been developed which describes the selectivity between liver and other target organs for a series of carcinogenic N-nitro-sodialkylamines. The relationship requires structural terms for the parent molecule as well as for the potential metabolites. This suggests that the nitrosamine metabolites are involved in tumor induction and that they participate directly in the mechanisms responsible for selecting the target organ.


Jan 1, 1978·Chemico-biological Interactions·J S WishnokW M Rand
Mar 1, 1975·Chemico-biological Interactions·O G Fahmy, M J Fahmy
Apr 1, 1971·Food and Cosmetics Toxicology·P N Magee
Nov 1, 1970·Journal of Medicinal Chemistry·J W McFarland
Jun 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·V J CABASSOM R STEBBINS

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Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L TurnerD Roberts
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May 5, 2007·Toxicology and Applied Pharmacology·Aliuska Morales HelgueraMiguel Angel Cabrera Pérez
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