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Nitrosation of phenacetin. Formation of N-nitroso-2-nitro-4-ethoxyacetanilide as an unstable product of the nitrosation in dilute aqueous-acidic solution

Arzneimittel-Forschung

Oct 1, 1975

G Eisenbrand, R Preussmann

PMID: 1040

Abstract

Reaction of phenacetin with N2O4 in glacial acetic acid at 10(0) C gives N-nitroso-2-nitro-4-ethoxyacetanilide. This N-nitrosoacylarylamine is stable at low temperatures (--30 degress C) but unstable at ambient temperature. No intact N-nitroso-2-nitro-4-ethoxyacetanilide can be detected...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Nitrogen Oxides
Nitroso Compounds
Nitrous Acid
Phenacetin
Mass Spectrometry
Tumor Promoters
Acetanilides
Thin Layer Chromatography
Drug Stability
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Nitrosation of phenacetin. Formation of N-nitroso-2-nitro-4-ethoxyacetanilide as an unstable product of the nitrosation in dilute aqueous-acidic solution

Arzneimittel-Forschung

Oct 1, 1975

G Eisenbrand, R Preussmann

PMID: 1040

DOI:

Abstract

Reaction of phenacetin with N2O4 in glacial acetic acid at 10(0) C gives N-nitroso-2-nitro-4-ethoxyacetanilide. This N-nitrosoacylarylamine is stable at low temperatures (--30 degress C) but unstable at ambient temperature. No intact N-nitroso-2-nitro-4-ethoxyacetanilide can be detected...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Nitrogen Oxides
Nitroso Compounds
Nitrous Acid
Phenacetin
Mass Spectrometry
Tumor Promoters
Acetanilides
Thin Layer Chromatography
Drug Stability

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