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Nitrosation of phenacetin. Formation of N-nitroso-2-nitro-4-ethoxyacetanilide as an unstable product of the nitrosation in dilute aqueous-acidic solution

Arzneimittel-Forschung

Oct 1, 1975

G Eisenbrand, R Preussmann

PMID: 1040

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Abstract

Reaction of phenacetin with N2O4 in glacial acetic acid at 10(0) C gives N-nitroso-2-nitro-4-ethoxyacetanilide. This N-nitrosoacylarylamine is stable at low temperatures (--30 degress C) but unstable at ambient temperature. No intact N-nitroso-2-nitro-4-ethoxyacetanilide can be detected...read more

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Drug Stability
Nitrous Acid
Phenacetin
Hydrogen-Ion Concentration
Acetanilides
Mass Spectrometry
Tumor Promoters
Nitrogen Oxides
Thin Layer Chromatography
Nitroso Compounds
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  • Nitrosation of phenacetin. Formation of N-nitroso-2-nitro-4-ethoxyacetanilide as an unstable product of the nitrosation in dilute aqueous-acidic solution

    Arzneimittel-Forschung

    Oct 1, 1975

    G Eisenbrand, R Preussmann

    PMID: 1040

    DOI:

    Abstract

    Reaction of phenacetin with N2O4 in glacial acetic acid at 10(0) C gives N-nitroso-2-nitro-4-ethoxyacetanilide. This N-nitrosoacylarylamine is stable at low temperatures (--30 degress C) but unstable at ambient temperature. No intact N-nitroso-2-nitro-4-ethoxyacetanilide can be detected...read more

    Mentioned in this Paper

    Drug Stability
    Nitrous Acid
    Phenacetin
    Hydrogen-Ion Concentration
    Acetanilides

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