PMID: 25738298Mar 5, 2015Paper

Nitroso-Redox Balance and Modulation of Basal Myocardial Function: An Update from the Italian Society of Cardiovascular Research (SIRC)

Current Drug Targets
Carlo G TocchettiPasquale Pagliaro

Abstract

Reactive oxygen species and reactive nitrogen species are produced endogenously by cardiomyocytes and are fundamental signaling molecules that regulate cellular function. Production of ROS and RNS is finely tuned to maintain proper myocardial function, but is altered in many pathophysiological conditions, therefore contributing to worsening myocardial dysfunction and ultimately heart failure. Indeed, an excess of ROS and RNS is central in many pathways leading to cardiac hypertrophy and failure, and the correct regulation of the nitroso-redox balance is fundamental for the function of the main components of the EC-coupling machinery. Broad antioxidant therapies have been proposed to improve myocardial function, but these therapies blunt even physiological ROS and RNS signaling, bringing limited, if any, beneficial effect. On the other hand, more targeted interventions on specific sources or pathways may produce promising results.

Citations

May 18, 2016·Journal of Cardiovascular Medicine·Christian CadedduGiuseppe Mercuro
May 18, 2016·Journal of Cardiovascular Medicine·Martino DeiddaGiuseppe Mercuro
Apr 12, 2017·Antioxidants & Redox Signaling·Carlo Gabriele TocchettiGiuseppe Mercuro
May 1, 2018·Journal of Cardiovascular Medicine·Christian Cadeddu DessalviGiuseppe Mercuro
Jun 11, 2019·Cardiac Failure Review·Alessandra CuomoValentina Mercurio
Oct 17, 2018·Current Medicinal Chemistry·Jacopo AgrimiVincenzo Lionetti
Oct 19, 2016·Journal of Cardiovascular Medicine·Christian CadedduGiuseppe Mercuro
Mar 23, 2018·Frontiers in Physiology·Gilda VarricchiCarlo G Tocchetti
Jul 10, 2020·Journal of Cardiovascular Translational Research·Kajaluxy Ananthan, Alexander R Lyon
Oct 19, 2016·Journal of Cardiovascular Medicine·Martino DeiddaGiuseppe Mercuro

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