PMID: 43013Jun 29, 1979

Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
O H Iversen

Abstract

Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.

Related Concepts

Malignant Neoplasm of Skin
Tumor Promoters
Tetrazolium Salts
Neoplasms
Tumor Lysis Syndrome
Acetone Measurement
Mice, Hairless
Methylnitrosourea
Nitrosourea Compounds
Mouse Skin

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