Nitrosylated proteins in monocytes as a new marker of oxidative-nitrosative stress in diabetic subjects with macroangiopathy.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
U JuliusI G Obrosova

Abstract

Peroxynitrite plays an important role in the pathogenesis of diabetic complications. Nitrosylated protein expression in peripheral blood monocytes reflects intracellular peroxynitrite injury, and thus could be a marker of higher diagnostic and prognostic value than plasma nitrotyrosine level. The purpose of this pilot study was to assess if peripheral blood monocytes of diabetic subjects accumulate nitrosylated proteins, and if nitrosylated protein expression correlates with blood glucose control, variables of lipid profile, C-reactive protein concentration (a marker of inflammation), and differs in patients with and without diabetic macrovascular and microvascular complications. Nitrosylated protein expression in peripheral blood monocytes (Western blot analysis) was assessed in 31 subjects with diabetes mellitus (29 Type 2, 2 Type 1; 20 males, 11 females; mean age 66 years). The presence of microangiopathy was defined by retinopathy, albumin excretion, and/or neuropathy, and macroangiopathy by carotid plaques, a history of myocardial infarction, and/or stroke. Diabetic subjects accumulated significant amounts of nitrosylated proteins in peripheral blood monocytes. Nitrosylated protein expression positively correlated with bod...Continue Reading

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Citations

Apr 15, 2014·European Journal of Pharmacology·Joseph Fomusi NdisangNina Lane
Jul 24, 2010·Current Atherosclerosis Reports·Patrick MurrayVasudevan A Raghavan
Jul 3, 2015·Experimental and Therapeutic Medicine·Amal Jamil FataniMohammed Mahboobuddin Ahmed
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Oct 21, 2009·Journal of Neurochemistry·Sukhdev Singh KambojRajat Sandhir
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Mar 25, 2016·The Journal of International Medical Research·Xiaozhen YeHong Du
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Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Israel Pérez-TorresVerónica Guarner-Lans

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