Nitrotyrosine immunostaining correlates with increased extracellular matrix: evidence of postplacental hypoxia

Placenta
Jerzy StanekL Myatt

Abstract

Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT immunostaining in 20 cases of perinatal mortality (13 stillbirths and seven cases of neonatal mortality) associated with PE, IDDM, amniotic fluid infection syndrome (AFIS), or from fetal/neonatal demise not related to these conditions (congenital anomalies) (n = five/group). Patients with PE have more decidual arteriolopathy and Tenney-Parker change, while patients with IDDM and ascending infection have more villous cytotrophoblastic hyperplasia. Archival paraffin-embedded placental sections were immunostained for NT for correlation with clinical features and H&E histological findings. The intensity of immunostaining for NT varied from absent (n = 7) to 1+ (n = 5) or 2+ (n = 8). All eight placentae with 2+ staining showed increased villous extracellular matrix (ECM), compared to none of five with 1+ staining and two of seven with no staining (chi2 = 14.3, P = 0.001). There was no statistically significant difference i...Continue Reading

References

Oct 1, 1987·American Journal of Obstetrics and Gynecology·R RomeroG W Duff
Aug 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H Fox
Apr 1, 1968·The Journal of Pathology and Bacteriology·H Fox
Apr 1, 1967·The Journal of Pathology and Bacteriology·H Fox
Jan 1, 1984·Archives of Pathology & Laboratory Medicine·G Altshuler
Feb 1, 1996·American Journal of Obstetrics and Gynecology·O S ReshetnikovaE I Fokin
Nov 19, 1997·Placenta·J C Kingdom, P Kaufmann
Dec 11, 1999·Gynecologic and Obstetric Investigation·U Mutlu-TürkogluM Uysal
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·C A Hubel
Jan 7, 2000·The American Journal of Pathology·A ManyY Zhou
Feb 29, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·P Zhang, K Benirschke
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S W WalshL J Roberts
Dec 1, 1964·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H FOX
Jun 1, 1965·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H FOX

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Citations

Aug 26, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jerzy Stanek
May 1, 2013·Archives of Pathology & Laboratory Medicine·Jerzy Stanek
May 31, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jerzy Stanek, Eric Weng
Feb 4, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Z GajD Nowakowska
Oct 9, 2009·European Journal of Clinical Investigation·M C PustovrhA Jawerbaum
Dec 18, 2008·Journal of Thrombosis and Haemostasis : JTH·L Myatt, R P Webster
Feb 1, 2011·The International Journal of Biochemistry & Cell Biology·Hung-Yi WuChiun-Jye Yuan
Feb 11, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jerzy Stanek, Hikmat A Al-Ahmadie
Oct 16, 2009·Virchows Archiv : an International Journal of Pathology·Jerzy Stanek
Sep 16, 2010·Annals of the New York Academy of Sciences·N VitoratosG Creatsas
Dec 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V H J RobertsL H Waters
Aug 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brenda-Louise GilesEva Nozik-Grayck
Jul 1, 2010·Archives of Pathology & Laboratory Medicine·Jerzy Stanek

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