Nitrous acid damage to duplex deoxyribonucleic acid: distinction between deamination of cytosine residues and a novel mutational lesion.

Journal of Bacteriology
A D FrankelP E Hartman

Abstract

The rate of nitrous acid deamination of labeled cytosine residues in native Escherichia coli deoxyribonucleic acid was monitored in vitro by release of acid-soluble counts after treatment with uracil deoxyribonucleic acid glycosylase. The reaction exhibited a lag and was not stimulate by several agents previously shown to enhance base substitution mutagenesis during nitrous acid treatment of duplex deoxyribonucleic acid. We conclude that a significant proportion of nitrous acid induced mutagenic lesions are novel lesions and not cytosine deaminations.

References

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Citations

Aug 1, 1986·Molecular & General Genetics : MGG·M MatsumuraS Aiba
Jan 1, 1994·Environmental and Molecular Mutagenesis·Z HartmanT A Cebula
Mar 28, 2009·Physical Chemistry Chemical Physics : PCCP·Vanessa LabetLeif A Eriksson
Jan 1, 1987·Mutation Research·L M Scearce, W E Masker
Jun 1, 1986·Microbiological Reviews·J P Claverys, S A Lacks
Jul 1, 1982·Journal of Bacteriology·A F Taylor, B Weiss
Jul 1, 1996·Chemical Research in Toxicology·S TamirS R Tannenbaum

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