PMID: 7091603Mar 1, 1982Paper

Nitrous oxide analgesia and altitude

Anaesthesia
M F JamesJ E Dennett

Abstract

The analgesic effectiveness of 50% nitrous oxide and oxygen or oxygen-enriched air, measured by variations in pain threshold, was studied at an altitude of 1460 m and simulated altitudes of sea level and 3300 m. At sea level pressures, 50% nitrous oxide exerted a similar analgesic effect to that found for morphine, raising the pain thresholds by a mean of 71.5%. At 1460 m, the increase in pain threshold produced was 40% and at 3300 m the increase in pain threshold was only 19%. The difference between the analgesic effects of nitrous oxide at each altitude was statistically significant. It is concluded that moderate altitudes significantly reduce the effectiveness of nitrous oxide in a manner directly related to the partial pressure of nitrous oxide at each altitude.

References

Feb 1, 1978·British Journal of Anaesthesia·M F JamesC P Rice
May 1, 1976·British Journal of Anaesthesia·J G WhitwamA Petrie
Dec 1, 1967·British Journal of Anaesthesia·G D PARBROOK

Citations

Oct 3, 2006·Current Opinion in Anaesthesiology·M F James
Nov 19, 2009·Journal of Anesthesia·Kay B Leissner, Feroze U Mahmood
May 15, 2008·Anaesthesia·P G Firth, K T S Pattinson
May 24, 2015·British Journal of Anaesthesia·M F M JamesM P W Grocott

Related Concepts

Altitude
Insufflation Anesthesia
Nitrous Oxide
Sensory Thresholds

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