Nitrous oxide increases the incidence of bowel distension in patients undergoing elective colon resection

Acta Anaesthesiologica Scandinavica
Ozan AkçaDaniel I Sessler

Abstract

Nitrous oxide rapidly inflates gas-filled spaces such as the intestines; but whether the resulting bowel distension is clinically important remains unclear. We therefore tested the hypothesis that nitrous oxide produces clinically important bowel distension. Patients scheduled for colon resection were anesthetized with isoflurane and 35% oxygen and randomly assigned to 65% nitrous oxide (n = 175) or 65% nitrogen in air (n = 169). At the end of surgery, blinded surgeons rated the degree of bowel distension as none, mild, moderate, or severe. Patients reported pain, and nausea and vomiting (PONV) 2 h after surgery. Data are reported as means (SD). P < 0.05 was statistically significant. Morphometric and demographic data were similar in the groups. The duration of surgery was 3.0 (1.2) h in the nitrous oxide group and 3.4 (1.5) h in the air group (P = 0.017). Postoperative self-reported pain scores (visual analog scale, 0-100 mm) were greater in the nitrous oxide group (43 [30] mm) than in the air group (35 [31] mm, P = 0.018). Although the incidence of PONV was similar in the groups, VAS scores for nausea were significantly greater in the nitrous oxide group (P = 0.040). Moderate-to-severe bowel distension was observed in 23% of ...Continue Reading

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Citations

Jan 30, 2010·Journal of Endourology·Ioannis VarkarakisCharalambos Deliveliotis
May 28, 2008·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Louise FergusonColin McKay
Mar 15, 2006·Current Opinion in Anaesthesiology·Mukadder Orhan-SungurOzan Akça
May 22, 2007·The Journal of Urology·Rizk El-GalleyYasser Sakawi
Sep 27, 2005·Lancet·Edith FleischmannUNKNOWN Outcomes Research Group
Jan 10, 2014·Anesthesiology·Philip J Peyton, Christine Yx Wu
Nov 7, 2015·The Cochrane Database of Systematic Reviews·Rao SunAkira Kuriyama
Aug 2, 2007·Anesthesiology·Paul S MylesUNKNOWN ENIGMA Trial Group
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioPierluigi Navarra
Dec 22, 2016·Inflammatory Bowel Diseases·Anita AfzaliScott D Lee
Mar 7, 2020·Immunopharmacology and Immunotoxicology·Monireh MohsenzadeganShahnam Sedigh Maroufi

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