Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress

Neurotoxicology
Sandeep Kumar SinghRamesh C Murthy

Abstract

Nitrous oxide (N₂O) toxicity can result in myelin loss and hyperhomocysteinemia similar to cobalamin (Cbl) deficiency. Studies on N₂O exposure can help in understanding the mechanism of demyelination. In view of paucity of studies on N₂O toxicity in rats this study was undertaken. Six male wistar rats were exposed to 1.5L/min N₂O with 1:1 O₂ for 90 min daily for 1 month. After 1-month exposure blood homocysteine (HCY) and oxidative stress parameters glutathione (GSH) and total antioxidant capacity (TAC) were measured. Brain and spinal cord was subjected to histopathological examination. The neurobehavioral changes, oxidative stress parameters and histopathological changes were correlated with serum B12 and HCY level. After 1-month exposure, the rats appeared sluggish, lethargic and developed predominantly hind limb weakness for 1-1.5h. In the exposed group, the total distance traveled (2001.66 ± 118.27 cm; p=0.037), time moving (80.16 ± 5.7s; p=0.028), number of rearing (10.33 ± 1.45; p=0.014) and grip strength (1042.40 ± 51.3N; p=0.041) were significantly decreased whereas, resting time significantly increased (219.83 ± 5.7s; p=0.030) compared to controls. Serum HCY level was significantly increased (20.56 ± 1.296 μm/ml; p=0.0...Continue Reading

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Citations

Feb 5, 2016·Molecular Neurobiology·Usha Kant MisraSushil Kumar Rahi
Sep 15, 2016·Neurology India·Usha Kant Misra, Jayantee Kalita
Aug 24, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Keith Fluegge
Sep 12, 2017·Biomarkers in Medicine·Keith Fluegge
Oct 15, 2019·Anesthesia and Analgesia·Jia L StevensDaniel S Martin
Oct 13, 2016·Environmental Science and Pollution Research International·Keith Fluegge
Nov 20, 2019·Anesthesia and Analgesia·Jia L StevensDaniel S Martin
Apr 20, 2019·Oxidative Medicine and Cellular Longevity·Sabrina de Carvalho CartágenesCristiane Socorro Ferraz Maia
Aug 5, 2019·Epilepsy Research·Usha K MisraMritunjai Kumar
Dec 12, 2020·BMJ Case Reports·Ramey AssafNigel Langford

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