PMID: 7521258Jun 1, 1994Paper

Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium

British Journal of Pharmacology
G KojdaE Noack

Abstract

1. Isolated segments of porcine vena cordis magna exhibited a reproducible contractile activity upon application of prostaglandin F2 alpha (PGF2 alpha) or KCl, that was independent of the presence of intact endothelium. Substance P (3 nM) elicited strictly endothelium-dependent relaxations amounting to 46.1 +/- 1.4% (n = 206) of contractions induced by 10 microM PGF2 alpha. 2. S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a compound that spontaneously liberates nitric oxide, concentration-dependently relaxed PGF2 alpha-precontracted (50 microM) venous segments. Tolerance induction (incubation with 100 microM SNAP for 30 min) within the same segments resulted in a 3 fold attenuation of this effect, which was not further reduced after additional preincubation with glyceryl trinitrate (GTN). Removal of endothelium or the presence of N omega-nitro-L-arginine methylester (L-NAME) significantly improved the potency of SNAP before and after tolerance induction. 3. Concentration-dependent relaxations induced by GTN in non-tolerant veins were similar in the presence and absence of endothelium but much more reduced in tolerant endothelium-denuded (75 fold) compared to intact (20 fold) segments. In contrast, the presence of L-NAME signific...Continue Reading

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Citations

Aug 15, 1995·European Journal of Pharmacology·S TsuchidaI Muramatsu
Feb 21, 2004·European Journal of Pharmacology·Ivan S de la LandeJohn D Horowitz
May 26, 1998·European Journal of Pharmacology·A PapapetropoulosJ D Catravas
Feb 12, 1998·British Journal of Pharmacology·G KojdaE Noack
Jan 1, 1996·British Journal of Pharmacology·A PapapetropoulosJ D Catravas
May 19, 2010·Biomarkers in Medicine·Bernhard R WinkelmannMartin Unverdorben
Apr 3, 2009·British Journal of Pharmacology·Karen L AndrewsBarbara K Kemp-Harper
Oct 23, 1997·Hypertension·W E HaefeliT F Lüscher
Aug 26, 2009·Fundamental & Clinical Pharmacology·Peyman U ErtuğErgin Singirik

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