Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties

Oxidative Medicine and Cellular Longevity
Mai E Shoman, Omar M Aly

Abstract

Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W P ArnoldF Murad
Oct 2, 1992·Journal of Medicinal Chemistry·M J LeeE G DeMaster
Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs
Jan 1, 1985·Critical Reviews in Toxicology·P Gross
Jan 1, 1980·The Journal of Small Animal Practice·I R GriffithsJ Barker
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·A J HobbsL J Ignarro
Jan 1, 1995·Annual Review of Physiology·O W Griffith, D J Stuehr
May 30, 1994·Biochemical and Biophysical Research Communications·R Z Pino, M Feelisch
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·H H SchmidtM Feelisch
Feb 12, 1998·Trends in Pharmacological Sciences·A J Hobbs
Mar 21, 1998·Archives of Biochemistry and Biophysics·D A WinkJ B Mitchell
Jun 11, 1998·Human Reproduction Update·M RosselliR K Dubey
Aug 26, 1998·Nitric Oxide : Biology and Chemistry·D W Shoeman, H T Nagasawa
Nov 4, 1998·Biochemistry·K M RuscheM A Marletta
Apr 21, 1999·Current Opinion in Cell Biology·A Ashkenazi, V M Dixit
May 8, 1999·Free Radical Biology & Medicine·J J PoderosoE Cadenas
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·X L MaM Feelisch
Oct 24, 2000·The Journal of Biological Chemistry·K M MirandaD A Wink
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D BartbergerK N Houk
Mar 29, 2001·Free Radical Biology & Medicine·A ReifH H Schmidt
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·N PaolocciD A Kass
Sep 13, 2001·Journal of Neurochemistry·C A ColtonS Vicini
Nov 17, 2001·European Journal of Pharmacology·B J De WittP J Kadowitz
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vladimir Shafirovich, Sergei V Lymar
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zhiqiang ChenJonathan S Stamler
Jun 18, 2002·European Journal of Pharmacology·Yuan-Jian Li, Jun Peng
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D BartbergerKendall N Houk

❮ Previous
Next ❯

Citations

Feb 23, 2018·BioFactors·Konstantin B ShumaevEnno K Ruuge
Dec 14, 2016·Angewandte Chemie·Praveen K ChinthakindiPer I Arvidsson
Jan 13, 2017·Oxidative Medicine and Cellular Longevity·Oxidative Medicine And Cellular Longevity
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sathyadevi PalanisamyYun-Ming Wang
Aug 24, 2017·European Journal of Pharmacology·Brandi M WynneR Clinton Webb

❮ Previous
Next ❯

Methods Mentioned

BETA
electron capture dissociation

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Current Topics in Medicinal Chemistry
Mai E Shoman, Omar M Aly
Antioxidants & Redox Signaling
Jon M Fukuto, Samantha J Carrington
Archives of Biochemistry and Biophysics
Christopher L BiancoJon M Fukuto
Archives of Pharmacal Research
Wilmarie Flores-SantanaDavid A Wink
© 2022 Meta ULC. All rights reserved