Nivalenol--induced apoptosis in thymus, spleen and Peyer's patches of mice

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Amnart PoapolathepKunio Doi

Abstract

ICR:CD-1 male mice were orally administered with Nivalenol(NIV) at the dose levels of 5, 10 and 15 mg/kg body weight, and examined at 12, 24 and 48 hours after inoculation (HAI), respectively, to elucidate the process of development of apoptosis in the thymus, spleen and Peyer's patch. There were no signs of clinical disorders and no changes in body and organ weights until 48 HAI except for that the thymus weight significantly decreased at 48 HAI. Immunohistochemically, the number of apoptotic lymphocytes evaluated by in situ detection for fragmented DNA showed a dose-dependent increase at 12 HAI in both the thymus and the Peyer's patch, while it became to increase at 24 HAI in the spleen. Dead lymphocytes in the thymus, spleen and Peyer's patch showed ultrastructural characteristics of apoptosis. Moreover, the DNA ladder was first detected by agarose gel electrophoresis at 12 HAI in the thymus of 15 mg/kg-group. The results clearly indicate that NIV is able to induce apoptosis in the lymphoid tissues of mice.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Oct 1, 1991·Poultry Science·A A Ademoyero, P B Hamilton
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·Y UenoY Matsuki
Dec 1, 1968·Chemical & Pharmaceutical Bulletin·T TatsunoH Tsunoda
May 1, 1995·Food Additives and Contaminants·H PetterssonO Fossum
Jan 1, 1993·International Archives of Occupational and Environmental Health·W SmoragiewiczK Krzystyniak
Jul 1, 1993·Bulletin of Environmental Contamination and Toxicology·M K GibsonR J Aulerich
Jan 1, 1993·Drug Metabolism Reviews·B Yagen, M Bialer
Dec 16, 1998·Virchows Archiv : an International Journal of Pathology·T IharaY Ueno

❮ Previous
Next ❯

Citations

Jul 16, 2005·Food Additives and Contaminants·O RochaF M Doohan
Sep 18, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Y Sugita-KonishiM Shibutani
Mar 31, 2009·International Journal of Molecular Sciences·Masayo Kushiro
Dec 17, 2009·International Journal of Food Microbiology·M PasqualiT Bohn
Sep 21, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Atsutaka KubosakiYoshiko Sugita-Konishi
Oct 28, 2006·Toxicologic Pathology·C Frieke Kuper
Apr 15, 2008·Arhiv za higijenu rada i toksikologiju·Marijana SokolovićBorka Simpraga
Aug 26, 2016·Journal of Toxicologic Pathology·Samak Sutjarit, Amnart Poapolathep
May 18, 2004·Archives of Environmental Health·Michael R GrayAristo Vojdani
May 18, 2004·Archives of Environmental Health·Aristo VojdaniAndrew W Campbell
Feb 19, 2019·Toxicon : Official Journal of the International Society on Toxinology·Sawinee AupanunAmnart Poapolathep
Nov 5, 2016·Toxicon : Official Journal of the International Society on Toxinology·Sawinee AupanunAmnart Poapolathep
May 6, 2019·Toxicon : Official Journal of the International Society on Toxinology·Sawinee AupanunAmnart Poapolathep
Sep 3, 2018·Toxicon : Official Journal of the International Society on Toxinology·Wanchalerm PhruksawanAmnart Poapolathep

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Journal of Food Sciences and Nutrition
Wafik S M RagabMarco Beyer
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T YabeY Ueno
Proceedings of the National Academy of Sciences of the United States of America
K AraseT Saito
Toxicology and Applied Pharmacology
C Y ChoiYoshiko Sugita-Konishi
© 2022 Meta ULC. All rights reserved