Nivolumab-induced cytokine-release syndrome in relapsed/refractory Hodgkin's lymphoma: a case report and literature review

Immunotherapy
Lingdi ZhaoQuanli Gao

Abstract

Hodgkin's lymphoma is a common malignant disease, especially among children in America. Although chemotherapy and radiotherapy are mainstay treatments for Hodgkin's lymphoma, a small portion of patient experiences relapsed or refractory diseases. Nivolumab provides an option for patients who experience relapsed or refractory disease, but adverse effects may occur. Here, we report a patient with relapsed/refractory Hodgkin's lymphoma who experienced cytokine-release syndrome after his first dose of nivolumab. The patient eventually experienced complete remission after his fifth dose of nivolumab. Cytokine-release syndrome might reflect good efficacy during treatment of relapsed/refractory Hodgkin's lymphoma with nivolumab. However, health care providers, should stay alert and take appropriate measures if adverse effects, such as cytokine-release syndrome, occur.

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Citations

May 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Gennaro CilibertoMarco G Paggi
Jan 17, 2021·Urologic Oncology·Shuchi GulatiSumanta K Pal
Apr 8, 2021·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Neeraj Chhabra, Joseph Kennedy
May 18, 2021·Frontiers in Immunology·Lele MiaoYumin Li
Jun 8, 2021·Frontiers in Oncology·Chen ZhangXiaodong Liu
Oct 3, 2020·Immunology Letters·Norbert Lukan

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Methods Mentioned

BETA
biopsy

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