Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma

Case Reports in Oncology
Keren RouvinovAlexander Yakobson

Abstract

Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. To the best of our knowledge, there are only three published case reports that have shown aplastic anemia in patients who have been treated by immunotherapy. This is the first report of a lethal aplastic anemia during nivolumab monotherapy in a metastatic melanoma patient.

References

Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J NaidooJ D Wolchok
Dec 7, 2016·Case Reports in Oncology·Amruth R PallaDonald Doll
Apr 14, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H HelgadottirG Masucci
Jul 4, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James LarkinJeffrey Weber
Sep 6, 2017·Melanoma Research·Akihiko YukiTakuro Ishiguro

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Citations

Mar 12, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rafaela KramerLucie Heinzerling

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Methods Mentioned

BETA
biopsy

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