Abstract
A 58-year-old man was diagnosed with lung adenocarcinoma with a tumor proportion score of 10%. After six cycles of second-line chemotherapy with nivolumab, he achieved a complete response (CR) but developed uveitis and sensorineural hearing disorder, which were consistent with Vogt-Koyanagi-Harada (VKH)-like syndrome. Simultaneously, pituitary adrenocortical insufficiency was identified. Nivolumab discontinuation and systemic corticosteroid administration resolved these immune-related adverse events (irAEs). The patient has maintained a CR without any chemotherapy for approximately two years. We herein report a patient with a long-term progression-free survival despite chemotherapy discontinuation due to irAEs, including VKH-like syndrome, which were appropriately managed.
References
Sep 1, 1990·Ophthalmology·J L DavisR B Nussenblatt
Mar 1, 1994·The British Journal of Ophthalmology·Y ShindoS Ohno
Feb 13, 2001·Tissue Antigens·S SaitoM Ota
Nov 20, 2008·Tissue Antigens·S Caillat-Zucman
Apr 9, 2010·International Ophthalmology Clinics·Luz Elena Concha del Río, Lourdes Arellanes-García
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
May 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lawrence H SchwartzLesley Seymour
Sep 22, 2016·The Journal of Dermatology·Takashi AraiRyoji Tsuboi
Feb 12, 2017·Cell·Padmanee SharmaAntoni Ribas
May 5, 2017·Clinical Case Reports·Toshihiko Matsuo, Osamu Yamasaki
Sep 25, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shunsuke TeraokaKeisuke Tomii
Oct 5, 2017·JAMA Oncology·Koji HarataniKazuhiko Nakagawa
Jan 2, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Koichi SatoNobuyuki Yamamoto
Mar 1, 2018·The Journal of Dermatology·Taku FujimuraSetsuya Aiba
Oct 13, 2018·Cancer Immunology, Immunotherapy : CII·Wei WangLing Chen
May 18, 2019·Case Reports in Ophthalmology·Shumpei ObataMasahito Ohji
Jun 26, 2020·BMC Ophthalmology·Ryo KikuchiKazuki Hotta