Nivolumab Treatment for Cancers in the HIV-infected Population

Journal of Immunotherapy
Elaine ChangElizabeth Y Chiao

Abstract

Nivolumab is a standard treatment option in several advanced malignancies, but safety and efficacy are still unknown in patients with human immunodeficiency virus (HIV) infection. We describe a case series of people living with HIV (PLWH) receiving nivolumab in the Veterans Health Administration (VA) and report responses and toxicities. We identified all PLWH who received nivolumab at any VA facility since 2000 in the Corporate Data Warehouse (CDW), which provides nationwide research access to VA electronic medical records. We identified 16 HIV-infected nivolumab recipients. The median number of nivolumab doses received was 6 (range, 1-32). Changes in CD4 count during therapy were variable, with 70% (7/10) of patients experiencing increases. Half of PLWH were treated for non-small-cell lung cancer; 2 for Hodgkin lymphoma (HL), 2 for renal cell carcinoma, and 4 for off-label cancers. For non-small-cell lung cancer, 7 patients had evaluable responses. Although 5 of 7 patients immediately progressed, 1 had a partial response and 1 had stable disease, which were both durable. Two of 16 (14%) PLWH had complete responses; both with HL (2/2 HL, 100%). The prevalence of immune-related adverse effects was 40% overall (6/15); 27% (4/15) ...Continue Reading

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Citations

Jan 29, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renée M Van der SluisSharon R Lewin
Aug 23, 2020·Current HIV/AIDS Reports·Kathryn LurainThomas S Uldrick
Aug 6, 2020·International Journal of Molecular Sciences·Ayumi KuzumeYosuke Minami
Sep 27, 2019·Frontiers in Immunology·Camille E PuronenThomas S Uldrick
Jun 27, 2020·AIDS·Ilaria ProiettiConcetta Potenza
Feb 17, 2019·The Annals of Pharmacotherapy·Jacqueline L OlinLinda M Spooner
Sep 9, 2019·Trends in Molecular Medicine·Michael S AbersDimitrios P Kontoyiannis
Dec 11, 2020·The Cancer Journal·Mitchell S von ItzsteinDavid E Gerber
Dec 29, 2020·Journal for Immunotherapy of Cancer·Sattva S NeelapuMichael R Bishop
Mar 28, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K RzeniewiczS Turajlic
Apr 23, 2021·Infectious Agents and Cancer·Mengmeng ZhangYu Zhang

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT02595866
NCT02408861

Software Mentioned

Excel
SPSS

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