Abstract
We studied the clinical role of leukocyte infiltration and chemokine receptor expression in ovarian carcinoma effusions. Expression of leukocyte markers (CD3, CD4, CD8, CD4/CD8 ratio, CD16, CD19, and CD14) and chemokine receptors (CXCR1, CXCR4, CCR2, CCR5, and CCR7) was studied in 73 effusions by using flow cytometry. CXCR4, CCR5, and CCR7 were expressed abundantly on leukocytes, but all receptors were expressed rarely on cancer cells. The presence of natural killer cells (P = .042) and International Federation of Gynecology and Obstetrics (FIGO) stage IV disease (P = .024) predicted worse overall survival (OS). A higher percentage of CD19+ cells (P = .015) and stage IV disease (P = .008) predicted poor survival for patients with postchemotherapy effusions. Only FIGO stage retained significance as a predictor of OS (P = .035) in multivariate analysis. Chemokine receptors are expressed widely on leukocytes but rarely on carcinoma cells in ovarian carcinoma effusions, arguing against an autocrine chemokine pathway in this malignancy. Immune response parameters in ovarian cancer effusions are weak predictors of outcome.
References
Apr 1, 1998·Journal of the National Cancer Institute·J YonedaI J Fidler
Jul 2, 1998·Clinical and Experimental Immunology·M A NashR S Freedman
Jan 20, 2000·Journal of the National Cancer Institute·F R Balkwill
Mar 4, 2000·The Journal of Biological Chemistry·G VenkatakrishnanJ E Groopman
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B DavidsonJ M Nesland
Oct 31, 2001·The American Journal of Surgical Pathology·B DavidsonP Johansen
Mar 27, 2002·Nature Reviews. Immunology·Bernhard HomeyAlbert Zlotnik
Apr 30, 2002·The Journal of Biological Chemistry·Evemie SchutyserJo Van Damme
Jul 12, 2002·American Journal of Clinical Pathology·Ben DavidsonBjørn Risberg
Oct 3, 2002·Cancer Immunology, Immunotherapy : CII·Ilona KryczekAndrzej Lange
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lei XuDai Fukumura
Mar 5, 2004·Breast Cancer Research and Treatment·Ben DavidsonJahn M Nesland
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Djordje AtanackovicSusanna Hegewisch-Becker
Aug 24, 2004·Nature Medicine·Tyler J CurielWeiping Zou
Sep 29, 2004·Diagnostic Cytopathology·Ben Davidson
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·T AbdollahiG Litwack
Sep 29, 2007·Cancer Science·Kei ShimizuKoichi Ohshima
Citations
Nov 16, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·V LavouéJ Levêque
Jul 31, 2009·PloS One·Katy MilneBrad H Nelson
Apr 6, 2011·Immunotherapy·Claudia C PrestonKeith L Knutson
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Rajesh SinghShailesh Singh
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marloes GoodenThorbald van Hall
Feb 1, 2013·Cancer Research·Monica BodogaiArya Biragyn
Sep 17, 2013·PloS One·Michael J BradaricJudith L Luborsky
Mar 3, 2015·Gynecologic Oncology·Christina WefersStanleyson V Hato
Jan 11, 2016·Journal of Internal Medicine·S MuenstS Hoeller
Apr 19, 2007·American Journal of Clinical Pathology·Ben DavidsonBjörn Risberg
Dec 3, 2013·Immunologic Research·Yu ZhangJoseph Rosenblatt
Jul 10, 2007·Immunology·Jennifer A BelisleManish S Patankar
Mar 28, 2008·Immunological Reviews·Brad H Nelson
Mar 11, 2015·Frontiers in Immunology·Claire GermainMarie-Caroline Dieu-Nosjean
May 18, 2016·Journal of Ovarian Research·Gloria MitticaGiorgio Valabrega
May 14, 2016·Gynecologic Oncology·Taylor B TurnerRebecca C Arend
Oct 28, 2016·PloS One·Mary Qu Yang, Laura Elnitski