PMID: 16613351Apr 15, 2006Paper

NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma

American Journal of Clinical Pathology
Hiep Phuc DongBjörn Risberg

Abstract

We studied the clinical role of leukocyte infiltration and chemokine receptor expression in ovarian carcinoma effusions. Expression of leukocyte markers (CD3, CD4, CD8, CD4/CD8 ratio, CD16, CD19, and CD14) and chemokine receptors (CXCR1, CXCR4, CCR2, CCR5, and CCR7) was studied in 73 effusions by using flow cytometry. CXCR4, CCR5, and CCR7 were expressed abundantly on leukocytes, but all receptors were expressed rarely on cancer cells. The presence of natural killer cells (P = .042) and International Federation of Gynecology and Obstetrics (FIGO) stage IV disease (P = .024) predicted worse overall survival (OS). A higher percentage of CD19+ cells (P = .015) and stage IV disease (P = .008) predicted poor survival for patients with postchemotherapy effusions. Only FIGO stage retained significance as a predictor of OS (P = .035) in multivariate analysis. Chemokine receptors are expressed widely on leukocytes but rarely on carcinoma cells in ovarian carcinoma effusions, arguing against an autocrine chemokine pathway in this malignancy. Immune response parameters in ovarian cancer effusions are weak predictors of outcome.

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Citations

Nov 16, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·V LavouéJ Levêque
Apr 6, 2011·Immunotherapy·Claudia C PrestonKeith L Knutson
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Rajesh SinghShailesh Singh
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marloes GoodenThorbald van Hall
Mar 3, 2015·Gynecologic Oncology·Christina WefersStanleyson V Hato
Jan 11, 2016·Journal of Internal Medicine·S MuenstS Hoeller
Apr 19, 2007·American Journal of Clinical Pathology·Ben DavidsonBjörn Risberg
Dec 3, 2013·Immunologic Research·Yu ZhangJoseph Rosenblatt
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Mar 11, 2015·Frontiers in Immunology·Claire GermainMarie-Caroline Dieu-Nosjean
May 18, 2016·Journal of Ovarian Research·Gloria MitticaGiorgio Valabrega
May 14, 2016·Gynecologic Oncology·Taylor B TurnerRebecca C Arend

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