NK and NKT cells have distinct properties and functions in cancer.

Oncogene
Xia LiuGuangyong Peng

Abstract

Natural killer (NK) and natural killer T (NKT) cells are two important cell subsets of the innate immune system. NK and NKT cells share many phenotypes and functions for anti-tumor immunity; however, the dynamic changes in phenotypes and functional interactions within the tumor microenvironment during tumor development and progression are unknown. Here we report that NK and NKT cells have distinct properties, metabolic profiles, and functions during tumor development. Using the mouse E0771 breast cancer and B16 melanoma models, we found that both NK and NKT cells are dynamically involved in the immune responses to cancer but have distinct distributions and phenotypic profiles in tumor sites and other peripheral organs during the course of tumor development and progression. In the early stages of tumor development, both NK and NKT cells exhibit effector properties. In the later cancer stages, NK and NKT cells have impaired cytotoxic capacities and dysfunctional states. NK cells become senescent cells, while NKT cells, other than invariant NKT (iNKT) cells, are exhausted in the advanced cancers. In contrast, iNKT cells develop increases in activation and effector function within the breast tumor microenvironment. In addition, sen...Continue Reading

References

Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Dec 23, 2004·Journal of Translational Medicine·Jana M SchüleAnnika Håkansson
Sep 3, 2005·The Journal of Clinical Investigation·Vrajesh V ParekhLuc Van Kaer
Oct 22, 2005·Nature Reviews. Immunology·Casey J FoxCraig B Thompson
Jul 25, 2008·Blood·Michael A Caligiuri
Dec 6, 2008·Advances in Cancer Research·Masaki Terabe, Jay A Berzofsky
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinichiro MotohashiToshinori Nakayama
Feb 24, 2009·Blood·Laura ChiossoneThierry Walzer
Dec 28, 2010·Current Opinion in Immunology·Thomas F GajewskiJustin Kline
Dec 28, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kazuki YamasakiYoshitaka Okamoto
May 11, 2011·The Journal of Clinical Investigation·Lukas BaitschDaniel E Speiser
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
Mar 23, 2012·Nature Reviews. Immunology·Eric VivierLaurent Brossay
Mar 27, 2012·Trends in Immunology·Lukas BaitschDaniel E Speiser
Jun 23, 2012·Blood·Jian YeGuangyong Peng
Jan 10, 2013·Annual Review of Immunology·Nancie J MacIverJeffrey C Rathmell
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian YeGuangyong Peng
Jun 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica J O'KonekJay A Berzofsky
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·June Ho ShinJohn B Sunwoo
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Mar 19, 2014·Seminars in Immunology·Nataliya ShifrinMichele Ardolino
Apr 2, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana StojanovicAdelheid Cerwenka
Jul 26, 2014·The Journal of Clinical Investigation·Duygu SagGerhard Wingender
Sep 19, 2014·EMBO Molecular Medicine·Jian YeGuangyong Peng
Oct 18, 2014·International Archives of Allergy and Immunology·Lorenzo MorettaMaria Cristina Mingari
Oct 21, 2014·The Journal of Clinical Investigation·Michele ArdolinoDavid H Raulet
Jan 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Molly P KeppelMegan A Cooper
May 6, 2015·Cancer Immunology Research·Rosanna M McEwen-SmithVincenzo Cerundolo
Aug 19, 2015·Cellular & Molecular Immunology·Tamara KrnetaAli A Ashkar
Jun 15, 2016·Pathogens and Disease·Tonya J WebbRandy R Brutkiewicz
Aug 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bojana Müller-DurovicArne N Akbar
Dec 3, 2016·Critical Reviews in Immunology·Annelise Y Mah, Megan A Cooper
Apr 20, 2017·Frontiers in Immunology·Clair M Gardiner, David K Finlay
Oct 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yeung-Hyen KimKalyani Pyaram

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