NK-associated regulatory receptors in a structured HAART interruption of HIV-1-positive individuals

AIDS Research and Human Retroviruses
J LuqueJ Peña

Abstract

Since highly active antiretroviral therapy (HAART) was introduced a decade ago, it has been shown to be effective in keeping HIV-1 replication under control. Nevertheless, it is also known that HAART has certain limitations, such as its inability to completely inhibit the viral replication that maintains virus reservoirs, its high toxicity when the treatment is maintained for long periods of time, and the appearance of viral resistance to the therapy. These limitations have led to the introduction of structured treatment interruption (STI) of antiretroviral therapy, the principle of which is to reduce the clinical complications of HAART, and hypothetically to boost the cellular immune response of the patient host. The aim of this study was to analyze for the first time the impact of STI on the innate immune system. Specifically, we analyzed NK cells and their regulatory receptors (KIRs, NKG2, NCRs, and ILTs) and the cytokines that might control the NK response. Six months after the initiation of STI, the results revealed in most patients a significant increase in NK cells expressing ILT2 and NKp46 receptors. Slight or no changes were observed in other parameters studied, either during interruption or when HAART was reintroduced...Continue Reading

References

Dec 29, 1998·Immunology Today·A RubartelliM R Zocchi
Mar 18, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N Clumeck, S De Wit
Apr 30, 2002·Current Opinion in Infectious Diseases·V Miller
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ume L Abbas, John W Mellors
Dec 5, 2002·Current Molecular Medicine·Daniel Scott-Algara, Pascale Paul
Feb 7, 2003·Current Medicinal Chemistry·L BelmonteB H Ruibal-Ares
Mar 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roberta CastriconiAlessandro Moretta
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel Scott-AlgaraGianfranco Pancino
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Domenico MavilioAnthony S Fauci
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Domenico MavilioAnthony S Fauci
Oct 20, 2005·The Journal of Infectious Diseases·Adrienne R ToulsonJulio S G Montaner
Oct 22, 2005·Nature Reviews. Immunology·Anthony S FauciShyam Kottilil
Feb 8, 2006·Health & Social Care in the Community·Helen Spandler, Nicola Vick
Jun 9, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sonia Molina-PineloManuel Leal
Sep 5, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jody LawrenceJohn D Baxter

❮ Previous
Next ❯

Citations

Apr 11, 2009·Current HIV/AIDS Reports·Kenneth A Lichtenstein
Jan 12, 2012·Viral Immunology·José PeñaUNKNOWN Dc2-Manon07 Vaccine Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.