NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin

Cancer Immunology, Immunotherapy : CII
Ming-Yu CaoAiping H Young

Abstract

Previous studies have demonstrated antitumor efficacy of Virulizin in several human tumor xenograft models and a critical role for macrophages in the antitumor mechanism of Virulizin. Although there is growing support for an immune stimulatory mechanism of action for Virulizin, the details remain to be elucidated. The aim of this study was to determine whether infiltration of natural killer (NK) cells into xenografted tumors is altered by Virulizin treatment, and whether such alterations contribute to the antitumor activity of Virulizin. Immunohistochemical analysis demonstrated that xenografted tumors from Virulizin-treated mice had an increase in infiltration of F4/80(+) (macrophages) and NK1.1(+) (NK) cells. The increase in NK1.1(+) cell infiltration occurred at an early stage of Virulizin treatment, which correlated with an early sign of apoptosis. In addition, Virulizin resulted in an increase in the number of NK cells in the spleens, and NK cells isolated from the spleen exhibited increased cytotoxicity to tumor cells in vitro. In NK cell-deficient SCID-beige mice, the antitumor activity of Virulizin was compromised, providing additional support to the hypothesis that NK cells are necessary for inhibition of tumor growth ...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 21, 1992·Journal of Immunological Methods·J BryantR B Herberman
Feb 15, 1990·International Journal of Cancer. Journal International Du Cancer·V SilobrcicR S Sedlacek
Apr 1, 1985·American Journal of Hematology·A Schattner, D B Duggan
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jan 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S MoriM Kyogoku
Dec 1, 1985·The Journal of Experimental Medicine·H G Ljunggren, K Kärre
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Jun 1, 1994·Experimental Cell Research·S KausalyaA Khar
Apr 1, 1996·Methods : a Companion to Methods in Enzymology·N L VujanovicT L Whiteside
Feb 1, 1997·Current Opinion in Immunology·L L Lanier
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·M Landström, K Funa
Aug 1, 1997·Current Opinion in Immunology·H Hengel, U H Koszinowski
Feb 28, 1998·Immunologic Research·G Trinchieri
Mar 5, 1998·Nature·V M BraudA J McMichael
Apr 2, 1999·Immunology and Cell Biology·H S Warren, M J Smyth
May 6, 1999·European Journal of Immunology·T KodamaK Okumura
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·K B Pham-NguyenS H Chen
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Sep 29, 1999·Cancer Immunology, Immunotherapy : CII·E Gilboa
Apr 19, 2000·The Journal of Experimental Medicine·L L Lanier
Jan 5, 2001·Expert Opinion on Investigational Drugs·E S FerdinandiG Ely
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V ScrepantiA Grandien
Aug 22, 2001·Immunological Reviews·A Cerwenka, L L Lanier
Aug 22, 2001·Immunological Reviews·A Diefenbach, D H Raulet
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BonnotteF Martin
Dec 26, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Francisco R VillegasLuis Callol
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Dengshun Miao, Andrew Scutt
Mar 7, 2002·International Reviews of Immunology·N L Vujanovic
Mar 22, 2002·Nature Reviews. Immunology·A Cerwenka, L L Lanier
May 8, 2002·The Journal of Clinical Investigation·Dengshun MiaoDavid Goltzman
Jun 28, 2002·Immunological Reviews·A Khar, R Anjum
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·George G ChenAlbert K K Chui

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Citations

Apr 13, 2012·Anti-cancer Drugs·Elena Victoria RoscaJohn Laterra
Dec 13, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Cristina NanniStefano Fanti
May 14, 2005·Cancer Immunology, Immunotherapy : CII·Hui LiAiping H Young
Mar 21, 2008·Cancer Immunology, Immunotherapy : CII·Tania BenatarAiping H Young
Dec 17, 2009·Cancer Immunology, Immunotherapy : CII·Tania BenatarAiping H Young
Sep 22, 2006·International Journal of Cancer. Journal International Du Cancer·Yi ZengEmmanuel Katsanis

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