NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface

Scientific Reports
Sandra M BloisSurendra Sharma

Abstract

DC-NK cell interactions are thought to influence the development of maternal tolerance and de novo angiogenesis during early gestation. However, it is unclear which mechanism ensures the cooperative dialogue between DC and NK cells at the feto-maternal interface. In this article, we show that uterine NK cells are the key source of IL-10 that is required to regulate DC phenotype and pregnancy success. Upon in vivo expansion of DC during early gestation, NK cells expressed increased levels of IL-10. Exogenous administration of IL-10 was sufficient to overcome early pregnancy failure in dams treated to achieve simultaneous DC expansion and NK cell depletion. Remarkably, DC expansion in IL-10-/- dams provoked pregnancy loss, which could be abrogated by the adoptive transfer of IL-10+/+ NK cells and not by IL-10-/- NK cells. Furthermore, the IL-10 expressing NK cells markedly enhanced angiogenic responses and placental development in DC expanded IL-10-/- dams. Thus, the capacity of NK cells to secrete IL-10 plays a unique role facilitating the DC-NK cell dialogue during the establishment of a healthy gestation.

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Citations

Apr 23, 2019·Clinical and Experimental Immunology·E GiacominiP Viganò
Mar 27, 2018·American Journal of Reproductive Immunology : AJRI·Shi-Bin ChengSurendra Sharma
Jul 19, 2019·F1000Research·Judith N Bulmer, Gendie E Lash
May 19, 2019·Animals : an Open Access Journal From MDPI·Leying ZhangLing Yang
Jun 18, 2020·Cancers·Elaheh Hashemi, Subramaniam Malarkannan

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Methods Mentioned

BETA
PCR
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FACS
flow cytometry

Software Mentioned

GraphPad Prism
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