NK cell enteropathy: a case report with 10 years of indolent clinical behaviour

Histopathology
James A IsomRobert W Allan

Abstract

Natural killer (NK) cell enteropathy is a recently described clinically indolent condition characterised by atypical NK cell infiltrates in the gastrointestinal mucosa that mimics malignant lymphoma. We report a case that highlights the indolent clinical behaviour by documenting absence of clinical progression over 10 years. We report the case of a 69-year old female who had clinically long-standing abdominal pain and recurrent mucosal ulcerations associated with atypical NK cell infiltrates. The clinical, morphologic and immunophenotypical findings in this case were diagnostic of NK cell enteropathy. Review of the patient's prior biopsies demonstrated that this persisted without clinical progression for 10 years, confirming the clinical indolent course. Recognition of NK cell enteropathy is important to avoid over-diagnosing this benign condition as an aggressive lymphoma.

References

Jan 1, 1989·Advances in Immunology·G Trinchieri
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J GaleD H Wright
Apr 18, 2006·Nature Immunology·Jacqueline G O'LearyUlrich H von Andrian
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Nov 25, 2006·Hematology·Elaine S Jaffe
Mar 9, 2010·Best Practice & Research. Clinical Gastroenterology·Jolanda M W van de WaterChris J J Mulder

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Citations

Jul 23, 2020·Virchows Archiv : an International Journal of Pathology·Jean-Louis DargentLaurence de Leval

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