NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Alaa Kassim AliSeung-Hwan Lee

Abstract

NK cells are innate lymphocytes capable of eliciting an innate immune response to pathogens. NK cells develop and become mature in the bone marrow (BM) before they migrate out to peripheral organs. Although the developmental program leading to mature NK cells has been studied in the context of several transcription factors, the stage-specific role of GATA3 in NK cell development has been incompletely understood. Using NKp46-Cre-Gata3(fl/fl) mice in which Gata3 deficiency was induced as early as the immature stage of NK cell differentiation, we demonstrated that GATA3 is required for the NK cell maturation beyond the CD27 single-positive stage and is indispensable for the maintenance of liver-resident NK cells. The frequencies of NK cells from NKp46-Cre-Gata3(fl/fl) mice were found higher in the BM but lower in peripheral organs compared with control littermates, indicating that GATA3 controls the maturation program required for BM egress. Despite the defect in maturation, upon murine CMV infection, NK cells from NKp46-Cre-Gata3(fl/fl) mice expanded vigorously, achieving NK cell frequencies surpassing those in controls and therefore provided comparable protection. The heightened proliferation of NK cells from NKp46-Cre-Gata3(fl/...Continue Reading

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T EvansG Felsenfeld
Aug 11, 2001·Current Opinion in Immunology·C A Biron, L Brossay
May 15, 2002·Nature Immunology·Sungjin KimWayne M Yokoyama
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khuong B NguyenChristine A Biron
Apr 16, 2004·Immunity·Michael J TownsendLaurie H Glimcher
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alina I MarusinaJohn E Coligan
Nov 8, 2005·Nature Immunology·Andrew M IntlekoferSteven L Reiner
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro Hayakawa, Mark J Smyth
Aug 15, 2006·Current Opinion in Cell Biology·Bing-Hao Luo, Timothy A Springer
Oct 3, 2006·Nature Immunology·Christian A J VosshenrichJames P Di Santo
May 1, 2007·Trends in Immunology·Seung-Hwan LeeChristine A Biron
Aug 25, 2007·Nature Reviews. Immunology·Nicholas D HuntingtonJames P Di Santo
Jan 30, 2008·Blood·Giovanni BernardiniAngela Santoni
Oct 17, 2008·Cancer Research·Marco WendelAdelheid Cerwenka
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nassima Fodil-CornuSilvia M Vidal
Feb 24, 2009·Blood·Laura ChiossoneThierry Walzer
Oct 8, 2009·The Journal of Experimental Medicine·Craig N JenneJerold Chun
Dec 10, 2009·The Journal of Experimental Medicine·Shintaro KamizonoTak W Mak
May 17, 2011·Advances in Immunology·David G T Hesslein, Lewis L Lanier
Oct 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsumi YoshizawaShinsuke Taki
Oct 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Emilie Narni-MancinelliEric Vivier
Feb 22, 2012·Nature Reviews. Immunology·Onur Boyman, Jonathan Sprent
Aug 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung-Hwan LeeChristine A Biron
Feb 7, 2013·Frontiers in Immunology·Giovanni BernardiniAngela Santoni
Mar 26, 2013·The Journal of Clinical Investigation·Hui PengZhigang Tian

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Citations

Nov 20, 2018·Immunology·Marc Brillantes, Aimee M Beaulieu
Nov 23, 2018·Open Biology·Nada Zaidan, Katrin Ottersbach
Apr 28, 2018·PLoS Biology·Yufeng WangJianhua Yu
May 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ricardo de Mendonça VieiraTamara Tilburgs
Mar 13, 2020·Frontiers in Immunology·Nuriban Valero-Pacheco, Aimee M Beaulieu
Aug 1, 2020·Frontiers in Immunology·Vladislava Stokic-TrticaChristoph S N Klose
Oct 9, 2018·Immunological Reviews·Francisca F AlmeidaGabrielle T Belz
Oct 24, 2018·Development·Mathieu TremblayMaxime Bouchard
Aug 28, 2020·Frontiers in Immunology·Jiacheng Bi, Xuefu Wang
Aug 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mir Munir A RahimAndrew P Makrigiannis
Mar 7, 2017·Frontiers in Immunology·Wilford Goh, Nicholas D Huntington
Jul 1, 2018·Cellular and Molecular Life Sciences : CMLS·Werner HeldMélanie Charmoy
Jun 21, 2020·Cancers·Dandan Wang, Subramaniam Malarkannan
Feb 14, 2021·Genomics, Proteomics & Bioinformatics·Shengquan ChenRui Jiang
Apr 17, 2021·Nature Immunology·Gabriela M WiedemannColleen M Lau

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