NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus

Journal of Virology
Teresa R JohnsonB S Graham

Abstract

CD1d-deficient mice have normal numbers of T lymphocytes and natural killer cells but lack Valpha14(+) natural killer T cells. Respiratory syncytial virus (RSV) immunopathogenesis was evaluated in 129xC57BL/6, C57BL/6, and BALB/c CD1d(-/-) mice. CD8(+) T lymphocytes were reduced in CD1d(-/-) mice of all strains, as shown by cell surface staining and major histocompatibility complex class I tetramer analysis, and resulted in strain-specific alterations in illness, viral clearance, and gamma interferon (IFN-gamma) production. Transient activation of NK T cells in CD1d(+/+) mice by alpha-GalCer resulted in reduced illness and delayed viral clearance. These data suggest that early IFN-gamma production and efficient induction of CD8(+)-T-cell responses during primary RSV infection require CD1d-dependent events. We also tested the ability of alpha-GalCer as an adjuvant to modulate the type 2 immune responses induced by RSV glycoprotein G or formalin-inactivated RSV immunization. However, immunized CD1-deficient or alpha-GalCer-treated wild-type mice did not exhibit diminished disease following RSV challenge. Rather, some disease parameters, including cytokine production, eosinophilia, and viral clearance, were increased. These findin...Continue Reading

References

Jun 1, 1976·The Journal of Allergy and Clinical Immunology·K McIntosh
Aug 1, 1990·The Journal of Infectious Diseases·A R FalseyR F Betts
Oct 1, 1988·Journal of Medical Virology·B S GrahamD T Karzon
Sep 1, 1988·The Journal of Experimental Medicine·M J CannonB A Askonas
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·N ShanksH Anisman
Nov 1, 1994·The Journal of Infectious Diseases·L J AndersonC R Bangham
Jan 1, 1994·The Journal of Experimental Medicine·W H AlwanP J Openshaw
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E WhimbeyG P Bodey
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
May 1, 1997·The Journal of Clinical Investigation·Y W Tang, B S Graham
Feb 17, 1998·European Journal of Immunology·T HussellP J Openshaw
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·O MandelboimJ L Strominger

❮ Previous
Next ❯

Citations

Dec 29, 2005·Journal of Clinical Immunology·Yuki Kinjo, Mitchell Kronenberg
Nov 7, 2007·Clinical Reviews in Allergy & Immunology·Robert C Welliver
Jun 18, 2002·Trends in Molecular Medicine·Michael T WilsonLuc Van Kaer
Oct 10, 2013·Mucosal Immunology·C Paget, F Trottein
Dec 5, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joyce E JohnsonBarney S Graham
May 10, 2007·Nature Reviews. Microbiology·Emmanuel TupinMitchell Kronenberg
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ashley L St JohnSoman N Abraham
Jul 29, 2004·Viral Immunology·Subramaniam KrishnanRobert C Welliver
Jun 10, 2004·Immunology and Cell Biology·Paul L Bollyky, S Brian Wilson
Jun 10, 2004·Immunology and Cell Biology·Serani L H Van Dommelen, Mariapia A Degli-Esposti
Jul 16, 2008·Clinical Microbiology Reviews·Shyam S Mohapatra, Sandhya Boyapalle
Jul 16, 2005·Clinical Microbiology Reviews·Peter J M Openshaw, John S Tregoning
Sep 23, 2003·Infection and Immunity·Markus Sköld, Samuel M Behar
Aug 8, 2008·Journal of Virology·Ikuo TsunodaRobert S Fujinami
Feb 22, 2008·Journal of Virology·Martin J RafteryGünther Schönrich
Mar 23, 2004·Annual Review of Immunology·Manfred Brigl, Michael B Brenner
May 29, 2010·Journal of Biomedicine & Biotechnology·Hiroyasu Ito, Mitsuru Seishima
Mar 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Kevin S HarrodMatthew D Reed
Nov 17, 2004·The Journal of Clinical Investigation·Dale I Godfrey, Mitchell Kronenberg
May 3, 2005·The Journal of Clinical Investigation·David Jesse SanchezDon Ganem
Oct 15, 2005·The Journal of Clinical Investigation·Edward S MorrisGeoffrey R Hill
Aug 23, 2005·Proceedings of the American Thoracic Society·R Stokes Peebles, Barney S Graham
Mar 31, 2009·Future Microbiology·Christine M OshanskyRalph A Tripp
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Lan Wu, Luc Van Kaer
Jun 20, 2014·PLoS Neglected Tropical Diseases·Ponpan MatangkasombutJuthathip Mongkolsapaya
Jul 31, 2007·Future Microbiology·Gerhard Wingender, Mitchell Kronenberg
Jul 24, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Victor Horácio de Souza CostaLucia de Noronha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.