Jul 28, 2009

NKG2D and its ligands

The International Journal of Biochemistry & Cell Biology
Peyman Obeidy, Alexandra Sharland

Abstract

NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals transmitted through inhibitory NK receptors, allowing NKG2D to function as a "master-switch" in determining the activation status of NK cells. NKG2D is important for T cell and NK cell-mediated immunity to viruses and tumours, and has roles in autoimmune disease, allogeneic transplantation, and xenotransplantation. Depending upon the situation, development of strategies to either block or to enhance the interactions between NKG2D and its ligands may have important implications for human health and disease.

  • References14
  • Citations23

Mentioned in this Paper

Src-Family Kinases
VAV1 gene
T-Lymphocyte
Phosphoric Monoester Hydrolases
Ligand Binding
NK Cell Lectin-Like Receptor Subfamily K, Member 1
CD28 gene
Human Herpesvirus 5 species
Transplantation Immunology
Protein Phosphorylation

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