PMID: 15239400Jul 9, 2004Paper

NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case

International Journal of Hematology
Sang Cheul OhJun Suk Kim

Abstract

Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.

References

Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·J S CheesbroughM E Molyneux
Sep 1, 1993·Journal of the National Cancer Institute·A M Levine
Mar 7, 2002·Critical Reviews in Oncology/hematology·Umberto TirelliEmanuela Vaccher
May 30, 2002·Archives of Pathology & Laboratory Medicine·Dennis B CornfieldLisa M Rimsza
Jul 3, 2002·Pathology, Research and Practice·María Victoria PreciadoElena De Matteo

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Citations

Jan 1, 2010·Journal of Hematopathology·Nicole C PanarelliAmy Chadburn
Jan 3, 2001·Clinics in Dermatology·J W Casiglia, S Woo
Jun 18, 2009·Current Opinion in Infectious Diseases·Tomas DoyleKate Cwynarski

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