Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number.

Developmental Biology
Kimara L TargoffD Yelon

Abstract

Heart formation is a complex morphogenetic process, and perturbations in cardiac morphogenesis lead to congenital heart disease. NKX2-5 is a key causative gene associated with cardiac birth defects, presumably because of its essential roles during the early steps of cardiogenesis. Previous studies in model organisms implicate NKX2-5 homologs in numerous processes, including cardiac progenitor specification, progenitor proliferation, and chamber morphogenesis. By inhibiting function of the zebrafish NKX2-5 homologs, nkx2.5 and nkx2.7, we show that nkx genes are essential to establish the original dimensions of the linear heart tube. The nkx-deficient heart tube fails to elongate normally: its ventricular portion is atypically short and wide, and its atrial portion is disorganized and sprawling. This atrial phenotype is associated with a surplus of atrial cardiomyocytes, whereas ventricular cell number is normal at this stage. However, ventricular cell number is decreased in nkx-deficient embryos later in development, when cardiac chambers are emerging. Thus, we conclude that nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Our data suggest that morphogenetic errors cou...Continue Reading

References

May 1, 1995·Pediatric Cardiology·J I Hoffman
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I Komuro, S Izumo
Dec 10, 1999·The Journal of Clinical Investigation·D W BensonJ D Kugler
Mar 8, 2000·Mechanisms of Development·C S NewmanP A Krieg
Mar 25, 2000·Molecular and Cellular Biology·M TanakaS Izumo
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·G S BairdR Y Tsien
Jul 31, 2001·Genesis : the Journal of Genetics and Development·B W DraperC B Kimmel
Dec 26, 2001·Nature Biotechnology·Brooke J Bevis, Benjamin S Glick
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Aug 14, 2002·Annals of Medicine·Owen W J PrallRichard P Harvey
Dec 7, 2002·Seminars in Cell & Developmental Biology·Nathalia S Glickman, Deborah Yelon
Nov 11, 2003·Journal of the American College of Cardiology·Doff B McElhinneyElizabeth Goldmuntz
Dec 19, 2003·Current Biology : CB·John D MablyMark C Fishman
May 8, 2004·Developmental Cell·Sigolène M MeilhacMargaret E Buckingham
Nov 24, 2005·Nature Reviews. Genetics·Margaret BuckinghamStéphane Zaffran
Sep 5, 2006·Mechanisms of Development·Bryan G AllenDaniel L Weeks
Jun 1, 2007·Development·Nathalia Glickman HoltzmanDeborah Yelon
Aug 8, 2007·Developmental Cell·Jeffrey J SchoenebeckDeborah Yelon
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Heather L BartlettDaniel L Weeks
Jan 19, 2008·Circulation Research·Stefan RohrSalim Abdelilah-Seyfried
Feb 22, 2008·Nature·Benoit G Bruneau

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Citations

Sep 15, 2012·Annual Review of Genetics·David Staudt, Didier Stainier
May 26, 2011·Nucleic Acids Research·Jean-Fred FontaineMiguel A Andrade-Navarro
Oct 21, 2011·BMC Developmental Biology·Samantha MaraghAndrew S McCallion
Oct 29, 2013·Nature Cell Biology·Noëlle Paffett-LugassyCaroline E Burns
Feb 24, 2016·Scientific Reports·Juan ZhouQing K Wang
Jul 31, 2012·Molecular and Cellular Endocrinology·Dinushan Nesan, Mathilakath M Vijayan
Jun 19, 2012·Differentiation; Research in Biological Diversity·Shu Tu, Neil C Chi
Jun 12, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daqing JinTao P Zhong
Mar 27, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ruilin Zhang, Xiaolei Xu
May 8, 2013·Genesis : the Journal of Genetics and Development·J S BennettD M Roden
Aug 21, 2010·Human Mutation·Stella Marie Reamon-Buettner, Juergen Borlak
May 24, 2014·Journal of Applied Toxicology : JAT·Ying HanChang-Qin Hu
Jul 2, 2014·Developmental Biology·Marcus-Oliver SchuppRamani Ramchandran
Jun 7, 2011·Developmental Biology·Ramón A Espinoza-LewisYiPing Chen
Jan 27, 2009·Developmental Biology·Ramón A Espinoza-LewisYiPing Chen
Jul 18, 2009·Developmental Biology·Lisa MavesStephen J Tapscott
May 6, 2016·Journal of Cardiovascular Development and Disease·Fei LuJau-Nian Chen
Nov 5, 2016·Cellular and Molecular Life Sciences : CMLS·Gianfranco MatroneMartin A Denvir
Jan 22, 2017·Genesis : the Journal of Genetics and Development·Jennifer M IkléDavid E Clouthier
Mar 2, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Huseyin C YalcinMagdi Yacoub
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Heng HuangYan Chen
Feb 25, 2014·Circulation Research·Yasuhiro NakashimaAtsushi Nakano
Jun 16, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jamie K HarringtonKimara L Targoff
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Kendall E Martin, Joshua S Waxman
Feb 26, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ekambaram PerumalSatheeswaran Balasubramanian
Mar 5, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jee-Hyun JungWon Joon Shim
Mar 15, 2021·Current Opinion in Hematology·Claudia Jasmin Rödel, Salim Abdelilah-Seyfried
Sep 13, 2013·Development·Kimara L TargoffDeborah Yelon

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