PMID: 9545546May 28, 1998Paper

Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS

Mechanisms of Development
Oliver PabstH H Arnold

Abstract

Nkx homeobox transcription factors are expressed in diverse embryonic cells and presumably control cell-type specification and morphogenetic events. Nkx2-9 is a novel family member of NK2 genes which lacks the conserved TN-domain found in all hitherto known murine Nkx2 genes. The prominent expression of Nkx2-9 in ventral brain and neural tube structures defines a subset of neuronal cells along the entire neuraxis. During embryonic development, Nkx2-9-expressing cells shift from the presumptive floor plate into a more dorsolateral position of the neuroectoderm and later become limited to the ventricular zone. Nkx2-9 expression overlaps with that of Nkx2-2 but is generally broader. While initially Nkx2-9 is expressed in close proximity to sonic hedgehog, its expression domain clearly segregates from sonic hedgehog at later developmental stages. The dynamic expression pattern of Nkx2-9 in ventral domains of the CNS is consistent with a possible role in the specification of a distinct subset of neurons.

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y Kim, M Nirenberg
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R S Mann
Jul 29, 1994·Cell·R Krumlauf
Dec 1, 1993·Molecular Endocrinology·D CivitarealeA Saiardi
Sep 15, 1996·Developmental Biology·R P Harvey
Nov 1, 1996·Circulation Research·I ShiojimaY Yazaki
May 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·O PabstH H Arnold
Nov 5, 1997·Mechanisms of Development·L Lemaire, M Kessel
May 1, 1997·Development Genes and Evolution·T BoettgerM Kessel

❮ Previous
Next ❯

Citations

Feb 19, 2000·Current Opinion in Neurobiology·R A Cornell, T V Ohlen
May 11, 2004·Nature Neuroscience·Alexandre PattynJean-François Brunet
May 11, 2005·PLoS Biology·Antigoni EkonomouVasso Episkopou
Jan 25, 2012·International Journal of Molecular Sciences·Arlene Bravo-Ambrosio, Zaven Kaprielian
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lan-Hsiang WangMarshall Nirenberg
Feb 16, 2007·Gene Expression Patterns : GEP·Simon G SprecherVolker Hartenstein
Aug 3, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R Shane TubbsAaron A Cohen-Gadol
Sep 21, 2012·Expert Opinion on Therapeutic Targets·Mehdi H ShahiJavier S Castresana
Mar 13, 2014·Developmental Biology·Lu ZhangChen-Leng Cai
Jun 7, 2005·Developmental Biology·Katja Seipel, Volker Schmid
Apr 28, 2004·Developmental Biology·Leigh WilsonMalcolm Maden
Oct 19, 2006·Developmental Biology·Matthias SchäferChristoph Winkler
Oct 28, 2014·Frontiers in Cellular Neuroscience·Nicolas Stifani
Apr 18, 2003·European Journal of Human Genetics : EJHG·Deepak KamnasaranDiane W Cox
Mar 23, 2001·Current Opinion in Neurology·M Pasqualetti, F M Rijli
Jan 28, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J CaiM Qiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.