nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish.

The Journal of Experimental Biology
Tetsuto MiyashitaW. Ted Allison

Abstract

The vertebrate jaw is a versatile feeding apparatus. To function, it requires a joint between the upper and lower jaws, so jaw joint defects are often highly disruptive and difficult to study. To describe the consequences of jaw joint dysfunction, we engineered two independent null alleles of a single jaw joint marker gene, nkx3.2, in zebrafish. These mutations caused zebrafish to become functionally jawless via fusion of the upper and lower jaw cartilages (ankylosis). Despite lacking jaw joints, nkx3.2 mutants survived to adulthood and accommodated this defect by: (a) having a remodeled skull with a fixed open gape, reduced snout and enlarged branchial region; and (b) performing ram feeding in the absence of jaw-generated suction. The late onset and broad extent of phenotypic changes in the mutants suggest that modifications to the skull are induced by functional agnathia, secondarily to nkx3.2 loss of function. Interestingly, nkx3.2 mutants superficially resemble ancient jawless vertebrates (anaspids and furcacaudiid thelodonts) in overall head shape. Because no homology exists in individual skull elements between these taxa, the adult nkx3.2 phenotype is not a reversal but rather a convergence due to similar functional requi...Continue Reading

References

Jul 1, 1971·American Journal of Orthodontics·B G Sarnat, H Muchnic
Jul 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E O Adekeye
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Apr 1, 1996·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·M M el-SheikhM H Warda
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K K Smith, R A Schneider
Jun 17, 1999·The British Journal of Oral & Maxillofacial Surgery·M M Chidzonga
Jul 6, 2000·Biological Reviews of the Cambridge Philosophical Society·P C DonoghueR J Aldridge
Sep 24, 2002·American Journal of Medical Genetics·Christiane SchifferConsolato Sergi
Mar 26, 2003·International Journal of Oral and Maxillofacial Surgery·L C Manganello-Souza, P B Mariani
Jun 1, 1955·American Journal of Physical Anthropology·S L HOROWITZ, H H SHAPIRO
May 7, 2004·Development·Craig T MillerCharles B Kimmel
Feb 11, 2005·The Journal of Biological Chemistry·Christopher J LengnerGary S Stein
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mary Jane West-Eberhard
Sep 15, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mary Jane West-Eberhard
Jan 20, 2006·Development·Sylvain ProvotAndrew B Lassar
Apr 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael J Depew, Carol A Simpson
Mar 16, 2007·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·L Patricia HernandezKatie Lynn Staab
Oct 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Patricia L Crotwell, Paula M Mabee
Mar 25, 2009·Experimental Cell Research·Satoshi YamashitaHiroshi Asahara
Jun 3, 2009·Brazilian Oral Research·Lucimar RodriguesJoão Gualberto de Cerqueira Luz
Dec 17, 2009·American Journal of Human Genetics·Jan HellemansGeert Mortier
Apr 27, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Burak BayramCanan Yazici
Sep 21, 2010·European Journal of Medical Genetics·Jean GekasDeepak Kamnasaran
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert CernyDaniel Meulemans Medeiros
Mar 25, 2011·Molecular Ecology Resources·Christian Peter Klingenberg
Nov 1, 2004·Integrative and Comparative Biology·Mark W Westneat
Nov 1, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·A Richard Palmer
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura N VandenbergMichael Levin
Jul 14, 2012·Brazilian Oral Research·Fernanda Engelberg Fernandes GomesJoão Gualberto de Cerqueira Luz
Sep 11, 2012·Developmental Biology·Daniel Meulemans Medeiros, J Gage Crump
Sep 29, 2012·Evolution & Development·Shigeru Kuratani
Feb 7, 2013·Nature Communications·J Andrew GillisClare V H Baker
May 24, 2013·Development·James T NicholsCharles B Kimmel
May 28, 2014·Nucleic Acids Research·Tessa G MontagueEivind Valen

❮ Previous
Next ❯

Citations

Jan 5, 2021·Genesis : the Journal of Genetics and Development·Brittany T Truong, Kristin B Artinger
Jan 29, 2022·Human Genetics·Sabrina C FoxAndrew J Waskiewicz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.