Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus

Proceedings of the National Academy of Sciences of the United States of America
B K BrottR L Erikson

Abstract

Extracellular-signal regulated kinases/microtubule-associated protein kinases (Erk/MAPKs) and cyclin-directed kinases (Cdks) are key regulators of many aspects of cell growth and division, as well as apoptosis. We have cloned a kinase, Nlk, that is a murine homolog of the Drosophila nemo (nmo) gene. The Nlk amino acid sequence is 54. 5% similar and 41.7% identical to murine Erk-2, and 49.6% similar and 38.4% identical to human Cdc2. It possesses an extended amino-terminal domain that is very rich in glutamine, alanine, proline, and histidine. This region bears similarity to repetitive regions found in many transcription factors. Nlk is expressed as a 4. 0-kb transcript at high levels in adult mouse brain tissue, with low levels in other tissues examined, including lung, where two smaller transcripts of 1.0 and 1.5 kb are expressed as well. A 4.0-kb Nlk message is also present during embryogenesis, detectable at day E10. 5, reaching maximal steady state levels at day E12.5, and then decreasing. Nlk transiently expressed in COS7 cells is a 60-kDa kinase detectable by its ability to autophosphorylate. Mutation of the ATP-binding Lys-155 to methionine abolishes its ability to autophosphorylate, as does mutation of a putative activa...Continue Reading

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J R BischoffD Beach
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E A Nigg
May 26, 1995·The Journal of Biological Chemistry·G ZhouJ E Dixon
Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Aug 1, 1994·Genes & Development·B D DynlachtE Harlow
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Blenis
Jun 1, 1996·Trends in Genetics : TIG·W Hanna-Rose, U Hansen
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·K L WatsonR L Erikson
Jul 1, 1997·Molecular and Cellular Biology·B D DynlachtL Zhu

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Citations

Sep 5, 2002·Journal of Cellular Biochemistry·Susumu HirabayashiYutaka Hata
May 9, 2000·Biochemical and Biophysical Research Communications·Y HuangB W Winston
Dec 1, 2011·Cellular and Molecular Neurobiology·Zhen LiZhengwen Lv
Nov 24, 1998·Trends in Genetics : TIG·J M ShulmanJ D Axelrod
Jul 28, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y MiyataE Nishida
Jun 6, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Junko Hyodo-MiuraHiroshi Shibuya
Mar 3, 2010·The Journal of Biological Chemistry·Meng LiLin Li
Jan 12, 2010·The Journal of Biological Chemistry·Sunhong KimJongkyeong Chung
Sep 30, 2010·Antioxidants & Redox Signaling·Anna A SzypowskaBoudewijn M T Burgering
Dec 2, 2010·Molecular Biology of the Cell·Shizuka IshitaniTohru Ishitani
Oct 27, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yuquan ZhangChun Cheng
Apr 15, 2004·Genes & Development·Chie Kanei-IshiiShunsuke Ishii
Sep 6, 2007·Molecular and Cellular Biology·Kiyotoshi SatohHiroshi Shibuya
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Marie Cargnello, Philippe P Roux
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyoungseok JuJanghoo Lim
Feb 1, 2007·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Jun Yasuda, Hitoshi Ichikawa
Jan 8, 2014·Journal of Molecular Neuroscience : MN·Dawei XuZhiming Cui
Mar 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hirotada KojimaKoichi Nakajima
Jun 14, 2014·Cell Death and Differentiation·H-H ZhangX-D Zhang
Mar 26, 2014·Journal of Cellular Physiology·Ernesto CanalisStefano Zanotti
Dec 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Dong YangRueyling Lin
Dec 24, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gang CuiAiguo Shen
Oct 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying HuangJun Li
Oct 21, 2009·Journal of Neurochemistry·Tohru IshitaniMotoyuki Itoh
Aug 7, 2003·Biochemical and Biophysical Research Communications·Jun YasudaSetsuo Hirohashi
Mar 10, 2001·Developmental Biology·S L RyuT Hirano
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ji-Rui DongYan Li
Sep 25, 2012·Cellular Signalling·Tohru Ishitani, Shizuka Ishitani
Jul 14, 2010·Biochimica Et Biophysica Acta·Hanna M PeltonenGeneviève Bart

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