NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi

Proceedings of the National Academy of Sciences of the United States of America
Jens HellerN Louise Glass

Abstract

In plants and metazoans, intracellular receptors that belong to the NOD-like receptor (NLR) family are major contributors to innate immunity. Filamentous fungal genomes contain large repertoires of genes encoding for proteins with similar architecture to plant and animal NLRs with mostly unknown function. Here, we identify and molecularly characterize patatin-like phospholipase-1 (PLP-1), an NLR-like protein containing an N-terminal patatin-like phospholipase domain, a nucleotide-binding domain (NBD), and a C-terminal tetratricopeptide repeat (TPR) domain. PLP-1 guards the essential SNARE protein SEC-9; genetic differences at plp-1 and sec-9 function to trigger allorecognition and cell death in two distantly related fungal species, Neurospora crassa and Podospora anserina Analyses of Neurospora population samples revealed that plp-1 and sec-9 alleles are highly polymorphic, segregate into discrete haplotypes, and show transspecies polymorphism. Upon fusion between cells bearing incompatible sec-9 and plp-1 alleles, allorecognition and cell death are induced, which are dependent upon physical interaction between SEC-9 and PLP-1. The central NBD and patatin-like phospholipase activity of PLP-1 are essential for allorecognition an...Continue Reading

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Citations

Dec 1, 2018·PLoS Genetics·Elizabeth Medina-CastellanosAlfredo Herrera-Estrella
Jul 22, 2020·Annual Review of Microbiology·Sven J Saupe
Jul 22, 2020·Annual Review of Microbiology·A Pedro GonçalvesN Louise Glass
Apr 20, 2019·Frontiers in Microbiology·Monika S Fischer, N Louise Glass
Jan 24, 2019·Frontiers in Plant Science·Xiquan GaoBaomin Feng
Apr 22, 2020·Communicative & Integrative Biology·A Pedro Gonçalves, N Louise Glass
Jul 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Asen DaskalovN Louise Glass
Oct 15, 2020·Cells·Alexander P MelaN Louise Glass
Feb 13, 2021·Prion·Asen Daskalov, Sven J Saupe
Jan 21, 2019·Biochemical Pharmacology·Madhura KulkarniJ Marie Hardwick
Oct 16, 2020·Journal of Molecular Biology·Witold DyrkaSven J Saupe
Jul 21, 2021·The ISME Journal·Karina Atriztán-Hernández, Alfredo Herrera-Estrella

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