NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4/NF-κB

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shu-Ren Ma, Xiong-Wei Xie

Abstract

The metabolic syndrome could be induced by high fat diet, leading to cardiovascular diseases, such as myocardial damage. Inflammation response and oxidative stress have been reported to be involved in high fat-induced heart injury, and the molecular mechanism is not fully understood. The NOD-like protein family member, NLRC5, could interact with IKKα to inhibit IKK complex activation. In our study, high fat diet-feeding mice showed cardiac fibrosis, inflammation and oxidative stress through collagen accumulation, TLR4/NF-κB and MAPKs signaling pathways activation. NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting α-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKKα, IκBα and NF-κB expression. And no effect on oxidative stress was observed in wild type and NLRC5-deficiency samples in in vivo studies. Moreover, NLRC5-knockout and -knockdown cardiac muscle cells challenged with LPS also exhibited aggravated fibrosis levels and inflammatory response without any influences on ROS production in in vitro studies. In conclusion, the findings indicated that NLRC5 showed important effects on high fat-induced heart injury via fibrosis and inflammation modulation, providing...Continue Reading

Citations

May 20, 2020·Anais Da Academia Brasileira De Ciências·Quan-Fang ChenDong-Ling Huang
Jul 2, 2020·Journal of Receptor and Signal Transduction Research·Linlin LiShiqing Hou
Aug 14, 2020·The Journal of International Medical Research·Zhen ZhangXin Chen
Dec 12, 2019·Frontiers in Pharmacology·Jie-Quan WangJun Li
Oct 15, 2018·Fertility and Sterility·Lei ZhanBing Wei
Feb 20, 2018·Developmental and Comparative Immunology·Lu CaoMing Xian Chang
Jul 25, 2021·International Journal of Molecular Sciences·Pengwei Li, Mingxian Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.