Abstract
NLRP3, a member of the nucleotide-binding oligomerization domain (NOD)-like receptor family, is involved in cardiac inflammation. However, the functional role of NLRP3 in cardiac remodeling is not clear. To investigate the roles of NLRP3 in pressure overload-induced cardiac remodeling, NLRP3 knockout and wild-type mice were subjected to aortic banding to induce cardiac remodeling. The data showed that NLRP3 expression was downregulated in the remodeling process. NLRP3 deficiency accelerated cardiac hypertrophy, fibrosis, and inflammation responses with deteriorating cardiac dysfunction in the pressure overload-induced cardiac remodeling mouse model. Neonatal rat cardiomyocytes were isolated and stimulated with phenylephrine (PE). We identified NLRP3 as a negative regulator of cardiomyocyte remodeling in PE-stimulated cardiomyocyte remodeling using adenovirus-NLRP3 and NLRP3 siRNA. Mechanistically, we found that the expression of Toll-like receptor (TLR) 4 was upregulated in NLRP3-deficient mouse hearts and PE-stimulated cardiomyocytes. NLRP3 knockout mice subjected to a TLR4 inhibitor revealed a relieved cardiac remodeling response with improved cardiac dysfunction. Our data suggested that NLRP3 could be a therapeutic target fo...Continue Reading
References
Nov 14, 2013·Cardiovascular Drugs and Therapy·Lalit P Singh
Feb 26, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Qing-Qing WuQi-Zhu Tang
Nov 7, 2015·Journal of Molecular and Cellular Cardiology·Neil A Turner
May 27, 2016·Cell Death & Disease·Y YangW Yi
Jun 2, 2016·Clinical and Experimental Pharmacology & Physiology·Sam Man LeeDavid A Saint
Sep 2, 2016·Clinical Science·Qing-Qing WuQi-Zhu Tang
Oct 8, 2016·Cellular and Molecular Life Sciences : CMLS·Zaffar K Haque, Da-Zhi Wang
Aug 27, 2017·Clinical Science·Qing-Qing WuQi-Zhu Tang
Nov 17, 2017·Nature Reviews. Cardiology·Stefano Toldo, Antonio Abbate
Dec 1, 2017·Frontiers in Pharmacology·Qing Q WuWei Deng
Dec 2, 2017·Inflammation·Di WuBin Wang
Dec 17, 2017·Oncotarget·Luís E PavillardMario D Cordero
Dec 24, 2017·International Immunopharmacology·Donglai MaLi Chu
Jan 21, 2018·Atherosclerosis·Gonzalo J MartínezSanjay Patel
Feb 14, 2018·Circulation·Ling ZhouDao Wen Wang
Feb 16, 2018·British Journal of Pharmacology·Qing-Qing WuQi-Zhu Tang
Mar 3, 2018·Osteoarthritis and Cartilage·M J McAllisterV E McGilligan
Mar 9, 2018·Frontiers in Physiology·Arpeeta SharmaJudy B de Haan
Mar 27, 2018·Mediators of Inflammation·Lili Yu, Zhiwei Feng
Mar 29, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luis E PavillardMario D Cordero
May 8, 2018·Autoimmunity Reviews·Hui-Hui ShenHai-Feng Pan
Citations
Feb 15, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Antun FerenčićHrvoje Jakovac
Jun 9, 2020·Clinical and Translational Medicine·Yucheng WangRuizhen Chen
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Chen LiuQizhu Tang
Jul 30, 2019·Frontiers in Immunology·Na AnYanwei Xing
Oct 17, 2020·Journal of Cellular and Molecular Medicine·Fangfang LiWenhao Qian
May 1, 2021·Cells·Lealem GedefawChien-Ling Huang
Jul 29, 2021·Arquivos brasileiros de cardiologia·Pedro Henrique Rizzi AlvesCamila Renata Corrêa
Jul 16, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Sergey V PopovJames M Downey
Jul 8, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fangfang LiQing Li
Aug 18, 2021·Toxicology and Applied Pharmacology·Xue TianMin Zhang
Nov 16, 2021·Shock·Qian LiMaolong Dong
Oct 7, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria L DiasFiona B McDonald