NLRP3 Inflammasome-A Key Player in Antiviral Responses.

Frontiers in Immunology
Chunyuan Zhao, Wei Zhao

Abstract

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1. This complex is crucial to the host's defense against microbes as it promotes IL-1β and IL-18 secretion and induces pyroptosis. NLRP3 recognizes variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) generated during viral replication that triggers the NLRP3 inflammasome-dependent antiviral immune responses and facilitates viral eradication. Meanwhile, several viruses have evolved elaborate strategies to evade the immune system by targeting the NLRP3 inflammasome. In this review, we will focus on the crosstalk between the NLRP3 inflammasome and viruses, provide an overview of viral infection-induced NLRP3 inflammasome activation, and the immune escape strategies of viruses through their modulation of the NLRP3 inflammasome activity.

References

Sep 16, 2003·FEBS Letters·Maria Eugenia Gonzalez, Luis Carrasco
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Sep 30, 2006·The Journal of Biological Chemistry·Thirumala-Devi KannegantiGabriel Núñez
Jun 30, 2007·Cell Death and Differentiation·V PétrilliJ Tschopp
Jul 8, 2008·Nature Immunology·Annett HalleDouglas T Golenbock
Jul 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz G BauernfeindEicke Latz
Apr 13, 2010·Nature Immunology·Takeshi IchinoheAkiko Iwasaki
Oct 29, 2010·Journal of Virology·A U BarlanC M Wiethoff
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Oct 14, 2011·Journal of Virology·Noritaka KomuneYusuke Yanagi
Aug 24, 2012·PLoS Pathogens·Minako ItoTakeshi Ichinohe
Sep 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moritz HaneklausSeth L Masters
Sep 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz BauernfeindVeit Hornung
Dec 5, 2012·PLoS Pathogens·Hilario J RamosMichael Gale
Dec 12, 2012·Biochimica Et Biophysica Acta·Sara M Ø SolbakTorgils Fossen
Jul 3, 2013·American Journal of Respiratory Cell and Molecular Biology·Kathy TriantafilouMartha Triantafilou
Sep 7, 2013·Intervirology·Juan C HernandezSilvio Urcuqui-Inchima
Oct 12, 2013·Frontiers in Immunology·Charles A DinarelloGilles Kaplanski
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Takeshi IchinoheYusuke Yanagi
Nov 28, 2013·Seminars in Immunology·Leo A B JoostenCharles A Dinarello
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Jun 3, 2014·Cell Reports·Monica YabalPhilipp J Jost
Feb 24, 2015·Advances in Virus Research·Stefanie Luecke, Søren R Paludan
Mar 31, 2015·Cell Host & Microbe·Arindam ChakrabartiRobert H Silverman
Jun 30, 2015·Cell Reports·Hongbin WangJianwei Wang
Nov 6, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiangnan LiChangjiang Weng

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Citations

Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeremy K Y YapAkiko Iwasaki
May 30, 2020·Aging·Amber L MuellerDavid A Sinclair
Aug 11, 2020·British Journal of Pharmacology·Ilaria BertocchiMassimo Collino
Jun 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shabnam Salimi, John M Hamlyn
Sep 23, 2020·Open Biology·Antonella FaraBakri M Assas
Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Rabia DenizAhmet Gül
Oct 2, 2020·Microbiology and Molecular Biology Reviews : MMBR·Huifang Zhu, Chunfu Zheng
Apr 22, 2020·Reviews in Medical Virology·George Anderson, Russel J Reiter
Jul 14, 2020·Frontiers in Immunology·Tracey L Freeman, Talia H Swartz
Jul 3, 2020·Immunity & Ageing : I & a·Caio Henrique Mazucanti, Josephine Mary Egan
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Gaurav ShrivastavaEric Calvo
Aug 26, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lolita S Nidadavolu, Jeremy D Walston
Aug 1, 2020·Cardiovascular Drugs and Therapy·Hazan KaradenizGiacomo Emmi
Sep 12, 2020·Cells·Pasquale CampanaAdriana Borriello
Sep 15, 2020·Frontiers in Pharmacology·Colleen S CurranJeffrey B Kopp
Jun 26, 2020·Frontiers in Cellular Neuroscience·Ya-Shuo FengFeng Zhang
Jun 21, 2020·British Journal of Pharmacology·Raul R Rodrigues-DiezMarta Ruiz-Ortega
Jan 7, 2021·Free Radical Research·Hung-Chi YangDaniel Tsun-Yee Chiu
Jan 9, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammad BahadoramMohammad-Reza Mahmoudian-Sani
Dec 11, 2020·International Immunopharmacology·Ritu Pasrija, Mohammad Naime
Aug 17, 2020·Scandinavian Journal of Immunology·Paulo A F Pacheco, Robson X Faria
Oct 30, 2020·Frontiers in Immunology·Maja Wyczanska, Bärbel Lange-Sperandio
Jan 30, 2021·Journal of Inflammation·Ali Saeedi-Boroujeni, Mohammad-Reza Mahmoudian-Sani
Feb 4, 2021·Journal of Inflammation Research·Bushra MdkhanaRabih Halwani
Oct 26, 2020·Basic & Clinical Pharmacology & Toxicology·Ali Saeedi-BoroujeniArash Alghasi
Nov 17, 2020·Frontiers in Immunology·Alberto López-ReyesGabriela Angélica Martínez-Nava
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mukesh ChourasiaAnil K Singh
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
Nov 11, 2020·Experimental Gerontology·Daniel J Moreno Fernández-AyalaGuillermo López-Lluch
Apr 30, 2021·Frontiers in Immunology·Jintao ZhangWei Zhao
May 9, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenwen WangWei Zhao

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Methods Mentioned

BETA
GTPase
ubiquitination

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