NLRP3 inflammasome activation in liver cirrhotic patients

Biochemical and Biophysical Research Communications
Xiao MaXiaohui Zhang

Abstract

NLRP3 inflammasome activation is involved in the mechanism of liver cirrhosis. In this study, we investigated the levels of plasma IL-1β and IL-18 and their relationship to component traits in patients with liver cirrhosis, and NLRP3 inflammasome expression in liver of patients with liver cirrhosis. A total of 75 patients with liver cirrhosis and 41 age-matched healthy control subjects were enrolled in this study. NLRP3 inflammasome expression and activation were measured in liver of patients with liver cirrhosis. Plasma IL-1β and IL-18 levels were examined by ELISA in patients with liver cirrhosis. Plasma IL-1β and IL-18 levels were also significantly higher in patients with liver cirrhosis than in control subjects. Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1β levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase. Plasma IL-18 levels were significantly negatively associated with albumin. NLRP3 and cleaved caspase-1 expression were increased in the livers of patients with cirrhosis compared with the livers of control subjects. Plasma IL-1β and IL-18 levels were higher in...Continue Reading

Citations

Sep 22, 2020·Clinical and Translational Gastroenterology·Sidsel StøyThomas Damgaard Sandahl
Nov 13, 2019·Epigenetics & Chromatin·Dandan ZongPing Chen
May 28, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaohui WangQiang Meng

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