NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection

Frontiers in Immunology
Augusto F ParoliSusana Gea

Abstract

Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that inflammasome activation and IL-1β induction by macrophages are key players for an appropriate T cell response, we investigated the relevance of NLR pyrin domain-containing 3 (NLRP3) and caspase-1/11 to elucidate their roles in the induction of different T cell phenotypes and the relationship with parasite load and hepatic inflammation during T. cruzi-Tulahuen strain acute infection. We demonstrated that infected nlrp3-/- and C57BL/6 wild type (WT) mice exhibited similar parasitemia and survival, although the parasite load was higher in the livers of nlrp3-/- mice than in those of WT mice. Increased levels of transaminases and pro-inflammatory cytokines were found in the plasma of WT and nlrp3-/- mice indicating that NLRP3 is dispensable to control the parasitemia but it is required for a better clearance of parasites in the liver. Importantly, we have found that NLRP3 and caspase-1/11-deficient mice differentially modulate T helper (Th...Continue Reading

References

Mar 7, 2007·Cytokine & Growth Factor Reviews·Wilson SavinoSusana Gea
Jan 24, 2009·The Journal of Clinical Investigation·Avlin B ImaedaWajahat Z Mehal
Aug 4, 2009·Current Opinion in Immunology·Angel M PadillaRick L Tarleton
Nov 26, 2009·Acta Tropica·Gabriel A Schmunis, Zaida E Yadon
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eva BillerbeckPaul Klenerman
Dec 29, 2010·Cell Research·Michael J Morgan, Zheng-gang Liu
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn TrandemStanley Perlman
Aug 27, 2011·Immunity·Nu Zhang, Michael J Bevan
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bianca ZingalesNancy R Sturm
Mar 10, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iris HitzlerAnne Müller
Mar 21, 2012·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Apr 3, 2012·Nature·Christina E ZielinskiFederica Sallusto
May 29, 2012·Infectious Disease Clinics of North America·Anis RassiJoffre Marcondes de Rezende
Mar 13, 2013·Current Opinion in Immunology·Catherine DostertGreta Guarda
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hai HuangAllan Tsung
Aug 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grace Kelly SilvaJoão Santana Silva
Oct 5, 2013·Cold Spring Harbor Symposia on Quantitative Biology·S Z Ben-SassonW E Paul
Oct 8, 2013·PLoS Neglected Tropical Diseases·Virginia M GonçalvesKarina R Bortoluci
Jul 16, 2014·Acta Tropica·Hector O RodriguezManuel Fresno
Aug 26, 2014·Nature Reviews. Immunology·Sarah L GaffenDaniel J Cua
Sep 27, 2014·International Reviews of Immunology·Yan LiangDong-Qing Ye
Apr 17, 2015·Immunological Reviews·Dario S Zamboni, Djalma S Lima-Junior
Aug 5, 2015·Journal of Immunology Research·Ana Flávia NardyAlexandre Morrot
Jan 26, 2016·The Journal of Clinical Investigation·Irma Garcia-MartinezWajahat Zafar Mehal
Feb 18, 2016·Acta biochimica Polonica·Sebastian WawrockiWieslawa Rudnicka
Apr 2, 2016·Cellular and Molecular Life Sciences : CMLS·Prajwal Gurung, Thirumala-Devi Kanneganti

❮ Previous
Next ❯

Citations

Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Tingdong YanWeifeng Huang
Sep 11, 2019·Cold Spring Harbor Perspectives in Biology·Carolyn A Lacey, Edward A Miao
Aug 18, 2020·Parasite Immunology·Damián Pérez-MazliahMichael D Lewis
Oct 16, 2018·Frontiers in Immunology·Jingyun Luan, Dianwen Ju
Dec 31, 2019·Cellular and Molecular Gastroenterology and Hepatology·Shi-Ying CaiJames L Boyer
Feb 20, 2021·Nature Immunology·Katherine A Deets, Russell E Vance
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fabio Marcelo CerbánClaudia Cristina Motran
Nov 24, 2019·Life Sciences·Ramesh Chandra Rai
Jun 19, 2021·Frontiers in Cellular and Infection Microbiology·Ranya ElsayedChristopher W Cutler

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
FACS
PMA
ELISA
flow cytometry
confocal microscopy

Software Mentioned

Flow Jo
Graph Pad Prism

Related Concepts

Related Feeds

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.