NLRP3 Inflammasome and Inflammatory Diseases

Oxidative Medicine and Cellular Longevity
Zheng WangLi Li

Abstract

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.

References

Aug 25, 2004·Investigative Ophthalmology & Visual Science·Archana ThakurLinda D Hazlett
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Feb 3, 2007·American Journal of Respiratory Cell and Molecular Biology·Aicha SaadaneMelvin Berger
Jun 30, 2007·Cell Death and Differentiation·V PétrilliJ Tschopp
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiwamu NakamuraKazuyoshi Kawakami
Dec 23, 2008·Nature Genetics·Alexandra-Chloé VillaniDenis Franchimont
Jun 9, 2009·Seminars in Immunology·Suzanne L CasselFayyaz S Sutterwala
Sep 1, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raúl Muñoz-PlanilloGabriel Núñez
Oct 7, 2009·The Journal of Cell Biology·Mohamed LamkanfiVishva M Dixit
Jan 23, 2010·The Journal of Biological Chemistry·Christine JulianaEmad S Alnemri
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Mar 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia TomaToshihiko Suzuki
Apr 22, 2010·Blood·Robin van BruggenTimo K van den Berg
Dec 24, 2010·Virulence·Sophie Joly, Fayyaz S Sutterwala
May 12, 2011·Inflammatory Bowel Diseases·Gregory J LewisMiles Parkes
Jun 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin WitzenrathBastian Opitz
Aug 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chengcheng JinRichard A Flavell
Oct 19, 2011·Gastroenterology·Grace Y Chen, Gabriel Núñez
Mar 14, 2012·Aging·Antero SalminenAnu Kauppinen
Mar 21, 2012·Nature Immunology·Luigi FranchiGabriel Núñez
Mar 21, 2012·Nature Immunology·Haitao WenLuke A J O'Neill
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tomohiko MurakamiTiffany Horng
Nov 29, 2012·Frontiers in Cellular and Infection Microbiology·Christelle Bourgeois, Karl Kuchler
Mar 7, 2013·Heart, Lung & Circulation·Fei ZhengQichong Xing
Apr 27, 2013·International Reviews of Immunology·Yuhui YangSvetlana Karakhanova

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Citations

Aug 31, 2020·Hypertension·Yongxin Li, Lilach O Lerman
Jun 26, 2020·Frontiers in Cellular Neuroscience·Ya-Shuo FengFeng Zhang
May 5, 2020·Current Pharmaceutical Design·Zeinab Nazarian-SamaniMahmoud Rafieian-Kopaei
Jan 3, 2021·Cellular and Molecular Neurobiology·Fillipe M de AraújoMaria Trinidad Herrero
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Jan 13, 2021·International Journal of Molecular Sciences·Valeria Di BattistaAlessandro Lucchesi
Jan 12, 2021·Frontiers in Immunology·Surabhi SurabhiNikolai Siemens
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Roberto De LucaSandra Incerpi
Apr 4, 2021·International Journal of Molecular Sciences·Camillo RicordiDavid Della-Morte
Apr 4, 2021·International Journal of Molecular Sciences·Jun-Hyuk HanKwang-Ho Lee
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
May 21, 2021·Frontiers in Pharmacology·Akash SaggamBhushan Patwardhan
Jul 3, 2021·International Journal of Molecular Sciences·Christine J Hawkins, Mark A Miles
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rajib DasMohammad S Mubarak
Aug 8, 2021·Journal of Clinical Medicine·Nasser M Al-DaghriSobhy M Yakout

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Methods Mentioned

BETA
nuclear translocation

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