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NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Nature Communications

Sep 26, 2019

Nour ErshaidNeta Erez

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Abstract

Cancer-Associated Fibroblasts (CAFs) were shown to orchestrate tumour-promoting inflammation in multiple malignancies, including breast cancer. However, the molecular pathways that govern the inflammatory role of CAFs are poorly characterised. In this study we found that fibroblasts sen...read more

Mentioned in this Paper

Tissue Adhesions
Malignant Neoplasm of Breast
Malignant Neoplasms
Fibroblasts
Inflammation
Interleukin-1 beta
Interleukin-1
Laboratory mice
Neoplasms
Up-Regulation (Physiology)
24
1
17
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NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Nature Communications

Sep 26, 2019

Nour ErshaidNeta Erez

PMID: 31558756

DOI: 10.1038/s41467-019-12370-8

Abstract

Cancer-Associated Fibroblasts (CAFs) were shown to orchestrate tumour-promoting inflammation in multiple malignancies, including breast cancer. However, the molecular pathways that govern the inflammatory role of CAFs are poorly characterised. In this study we found that fibroblasts sen...read more

Mentioned in this Paper

Tissue Adhesions
Malignant Neoplasm of Breast
Malignant Neoplasms
Fibroblasts
Inflammation
24
1
17

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